Table 2 Symptoms and signs other than diarrhea in 30 volunteers experimentally infected with ETEC strain TW10598
Target dose (CFU) | 1 × 106 | 1 × 107 | 1 × 108 | 1 × 109 |
|---|---|---|---|---|
No. of volunteers | 3 | 8 | 7 | 12 |
Nausea | 1 (33%) | 5 (63%) | 5 (71%) | 7 (58%) |
Abdominal pain | 0 | 4 (50%) | 7 (100%) | 7 (58%) |
Abdominal cramping | 0 | 1 (13%) | 7 (100%) | 6 (50%) |
Excessive flatus | 1 (33%) | 1 (13%) | 5 (71%) | 5 (42%) |
Decreased appetite | 0 | 2 (25%) | 5 (71%) | 5 (42%) |
Bloating | 1 (33%) | 0 | 0 | 6 (50%) |
Vomiting | 0 | 1 (13%) | 0 | 2 (17%) |
Constipation | 0 | 0 | 0 | 1 (8%) |
Headache | 2 (67%) | 2 (25%) | 4 (57%) | 5 (42%) |
Malaise | 0 | 2 (25%) | 4 (57%) | 5 (42%) |
Fever | 0 | 4 (50%) | 1 (14%) | 2 (17%) |
Chills | 0 | 1 (13%) | 1 (14%) | 4 (33%) |
Myalgias | 0 | 1 (13%) | 0 | 4 (33%) |
Lightheadedness | 0 | 2 (25%) | 0 | 1 (8%) |
Hypovolemia | 0 | 0 | 0 | 0 |