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Table 1 Proportion of subjects with diarrhea, incubation period, stool output and episode duration among 30 volunteers experimentally infected with ETEC strain TW10598 (STh LT-CS2 CS3 CS21; O6:K15:H16)

From: Experimental infection of healthy volunteers with enterotoxigenic Escherichia coliwild-type strain TW10598 in a hospital ward

Target dose (CFU)

No. of volunteers

No. with diarrhea

Attack risk

Median severity

Mean incubation period, hours (range)

Mean 24 hrs maximum stool output, grams (range)

Mean whole episode stool output, grams (range)

Mean episode duration, hrs (range)

Mean 24 hrs maximum stool output, count (range)

1 × 106

3

2

67%

Mild-Moderate

60 (48–72)

416 (330–502)

613 (510–717)

37 (25–48)

2 (2–2)

1 × 107

8

5

63%

Moderate

37 (9–70)

676 (407–1352)

877 (407–1842)

38 (6–72)

5 (3–9)

1 × 108

7

6

86%

Moderate-Severe

38 (13–78)

965 (318–1790)

1466 (450–3608)

46 (18–78)

6.5 (3–13)

1 × 109

12

10

83%

Moderate

30 (10–57)

538 (295–918)

687 (358–1315)

33 (1–106)

4.2 (1–9)