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Table 3 Reproduction numbers from the 1968 influenza A/H3N2 pandemic

From: Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature

Location Wavea Study population Mean GT/SIb Reproduction number (R) 95% CIc Basic or effective Case definition Reference Year published
Hong Kong 1st Community 2.95 1.89   Basic Unconfirmed illness [42] 1986
various 1st Community 4 1.06–2.06   Basic Serology; laboratory confirmed illness; unconfirmed illness [43] 2010
various 1st Confined settings 4 1.08–1.62   Basic Serology; laboratory confirmed illness; unconfirmed illness [43] 2010
United Kingdom 1st Community 4.1 1.80   Effective Unconfirmed illness [25] 2006
United Kingdom 2nd Community NR 1.85   Effective Serology confirmed infection [26] 2005
various 2nd Community 4 1.08–2.02   Effective Serology; laboratory confirmed illness; unconfirmed illness [43] 2010
various 2nd Confined settings 4 1.43 1.23–1.63 Effective Serology; laboratory confirmed illness; unconfirmed illness [43] 2010
Median reproduction number for the 1968 pandemic: 1.80; Interquartile range 1.56–1.85.
  1. aThe 1968 influenza A/H3N2 pandemic began in Hong Kong in July 1968. Large single waves of illness were reported in the Northern Hemisphere between September 1968 and April 1969 (with peaks occurring in December 1968–January 1969). Large single waves of illnesses were reported in the Southern Hemisphere between June and September 1969. Some countries in the Northern Hemisphere, such as the United Kingdom, did not have an outbreak of H3N2 until the winter of 1969–70.
  2. bThe generation time (GT) or serial interval (SI) assumed in the reproduction number estimation.
  3. cConfidence interval.
  4. NR = Not reported.
  5. This table is also available as a .csv file as Additional file 3.