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Table 2 Susceptibility and resistance profile of M. tuberculosis genotypes to first and second line anti-mycobacterium drugs

From: Molecular detection and characterization of resistant genes in Mycobacterium tuberculosis complex from DNA isolated from tuberculosis patients in the Eastern Cape province South Africa

  TB resistance profiles to first line (FL) drugs TB resistance profiles to second line (SL) drugs
Parameter INH RIF STM EMB MDR ETHIO OFL CAP AMIK Pre-XDR XDR
Age N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%)
≤ 20 23 (12.1) 22 (11.6) 12 (6.3) 2 (1.1) 22 (11.6) 2 (1.1) 1 (0.53) 2 (1.1) 4 (2.1) 2 (1.1) 23 (12.1)
21–40 114 (60) 114 (60) 73 (38.4) 20 (10.5) 114 (60) 23 (12.1) 30 (15.8) 7 (3.6) 58 (30.5) 18 (9.4) 83 (43.7)
41–60 46 (24.2) 46 (24.2) 21 (11.1) 3 (1.58) 46 (24.2) 5 (2.63) 3 (1.6) 4 (2.1) 18 (9.5) 12 (6.3) 46 (24.2)
≥61 5 (2.6) 5 (2.6) 2 (1.1) 0 (0) 5 (2.6) 2 (1.1) 2 (1.1) 0 (0) 3 (1.6) 1 (0.53) 5 (2.6)
Total 188 (98.9) 187 (98.4) 108 (56.8) 25 (12.7) 187 (98.4) 32 (16.8) 36 (18.9) 13 (6.8) 83 (43.7) 33 (17.4) 157 (82.6)
Gender            
Male 85 (43) 84 (42.6) 47 (23.5) 8 (4) 84 (42.6) 17 (8.6) 14 (7.1) 5 (2.5) 36 (18.2) 17 (8.6) 85 (38)
Female 105 (55.3) 105 (55.3) 60 (31.6) 10 (5.3) 105 (55.3) 15 (7.9) 22 (11.6) 8 (4.21) 47 (24.7) 16 (8.42) 85 (44.7)
Total 190 (100%) 189 (99.5) 107 (56.3) 18 (9.5) 189 (99.5) 32 (16.8) 36 (18.9) 13 (6.8) 83 (43.7) 33 (17.4) 157 (82.6)
  1. INH = isoniazid, RIF = rifampicin, STM = streptomycin; EMB = ethambutol; MDR = multi-resistant drug, ETHIO = ethionimide, OFL = ofloxacin, CAP = capreomycin, AMIK = amykacin, pre-XDR = pre-extensively drug resistant, XDR = extensively drug resistant.