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Table 2 Susceptibility and resistance profile of M. tuberculosis genotypes to first and second line anti-mycobacterium drugs

From: Molecular detection and characterization of resistant genes in Mycobacterium tuberculosis complex from DNA isolated from tuberculosis patients in the Eastern Cape province South Africa

 

TB resistance profiles to first line (FL) drugs

TB resistance profiles to second line (SL) drugs

Parameter

INH

RIF

STM

EMB

MDR

ETHIO

OFL

CAP

AMIK

Pre-XDR

XDR

Age

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

≤ 20

23 (12.1)

22 (11.6)

12 (6.3)

2 (1.1)

22 (11.6)

2 (1.1)

1 (0.53)

2 (1.1)

4 (2.1)

2 (1.1)

23 (12.1)

21–40

114 (60)

114 (60)

73 (38.4)

20 (10.5)

114 (60)

23 (12.1)

30 (15.8)

7 (3.6)

58 (30.5)

18 (9.4)

83 (43.7)

41–60

46 (24.2)

46 (24.2)

21 (11.1)

3 (1.58)

46 (24.2)

5 (2.63)

3 (1.6)

4 (2.1)

18 (9.5)

12 (6.3)

46 (24.2)

≥61

5 (2.6)

5 (2.6)

2 (1.1)

0 (0)

5 (2.6)

2 (1.1)

2 (1.1)

0 (0)

3 (1.6)

1 (0.53)

5 (2.6)

Total

188 (98.9)

187 (98.4)

108 (56.8)

25 (12.7)

187 (98.4)

32 (16.8)

36 (18.9)

13 (6.8)

83 (43.7)

33 (17.4)

157 (82.6)

Gender

           

Male

85 (43)

84 (42.6)

47 (23.5)

8 (4)

84 (42.6)

17 (8.6)

14 (7.1)

5 (2.5)

36 (18.2)

17 (8.6)

85 (38)

Female

105 (55.3)

105 (55.3)

60 (31.6)

10 (5.3)

105 (55.3)

15 (7.9)

22 (11.6)

8 (4.21)

47 (24.7)

16 (8.42)

85 (44.7)

Total

190 (100%)

189 (99.5)

107 (56.3)

18 (9.5)

189 (99.5)

32 (16.8)

36 (18.9)

13 (6.8)

83 (43.7)

33 (17.4)

157 (82.6)

  1. INH = isoniazid, RIF = rifampicin, STM = streptomycin; EMB = ethambutol; MDR = multi-resistant drug, ETHIO = ethionimide, OFL = ofloxacin, CAP = capreomycin, AMIK = amykacin, pre-XDR = pre-extensively drug resistant, XDR = extensively drug resistant.