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Table 1 Patient and site characteristics (independent variables) collected from patient charts

From: Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections: a multi-country medical chart review in Europe

Type of data collected Pre-specified as clinically relevant (always included in models) Considered in models only if marginally statistically significant (p < 0.1)
Patient baseline characteristics • Age (later removed), Country, • Patient living arrangements (for IV-only, IV-to-oral, ES models),
  • Patient living arrangements (for LOS, ED models) • Employment status
  • Charlson comorbidity index • History of diabetes
  • IV drug abuse • History of diabetes with end organ damage
   • History of peripheral vascular disease
   • History of dementia
   • Any MRSA colonization before admission
Infection/treatment characteristics • cSSTI type • Days from admission to cSSTI index date
  • cSSTI location • Initial antibiotic therapy was MRSA active
  • cSSTI source • Time to initiating MRSA-active therapy
  • Days to first MRSA culture  
  • Any surgical procedures for cSSTI  
  • IV-to-oral antibiotic switch (vs IV-only; except for IV-to-oral antibiotic switch model)  
Complications   • Superinfection
   • Serious adverse event
   • Severe sepsis
   • Developed IV line infection
Hospital characteristics   • Discharge physician specialty, Type of hospital
   • Overall hospital beds,
   • Hospital has an ED protocol (IV-to-oral antibiotic switch or OPAT),
   • Hospital has an IV-to-oral antibiotic switch protocol
  1. Abbreviations: cSSTI, complicated skin and soft tissue infection; IV, intravenous; ED, early discharge; ES, early switch; LOS, length of hospital stay; MRSA, methicillin-resistant Staphylococcus aureus; OPAT, outpatient parenteral antibiotic therapy. Add OPAT?