Table 1 Patient and site characteristics (independent variables) collected from patient charts
Type of data collected | Pre-specified as clinically relevant (always included in models) | Considered in models only if marginally statistically significant (p < 0.1) |
|---|---|---|
Patient baseline characteristics | • Age (later removed), Country, | • Patient living arrangements (for IV-only, IV-to-oral, ES models), |
|  | • Patient living arrangements (for LOS, ED models) | • Employment status |
|  | • Charlson comorbidity index | • History of diabetes |
|  | • IV drug abuse | • History of diabetes with end organ damage |
|  |  | • History of peripheral vascular disease |
|  |  | • History of dementia |
|  |  | • Any MRSA colonization before admission |
Infection/treatment characteristics | • cSSTI type | • Days from admission to cSSTI index date |
|  | • cSSTI location | • Initial antibiotic therapy was MRSA active |
|  | • cSSTI source | • Time to initiating MRSA-active therapy |
|  | • Days to first MRSA culture |  |
|  | • Any surgical procedures for cSSTI |  |
|  | • IV-to-oral antibiotic switch (vs IV-only; except for IV-to-oral antibiotic switch model) |  |
Complications |  | • Superinfection |
|  |  | • Serious adverse event |
|  |  | • Severe sepsis |
|  |  | • Developed IV line infection |
Hospital characteristics |  | • Discharge physician specialty, Type of hospital |
|  |  | • Overall hospital beds, |
|  |  | • Hospital has an ED protocol (IV-to-oral antibiotic switch or OPAT), |
|  |  | • Hospital has an IV-to-oral antibiotic switch protocol |