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Figure 6 | BMC Infectious Diseases

Figure 6

From: Automated image-based assay for evaluation of HIV neutralization and cell-to-cell fusion inhibition

Figure 6

Comparisons of neutralization results generated by the automated plaque reduction (APR) assay with that of pseudovirus (PSV) based and peripheral blood mononuclear cell (PBMC) based assays. Circular “radar” plots of 50% inhibitory concentration-(IC50) values across (a) viruses and (b) plasma for the PSV assay (blue lines), the PBMC assay (red lines) and the APR assay (green lines). The radial axes extending from the plot center represent a particular (a) plasma and (b) virus for each axis. The radial scale is normalized, with the center representing no neutralization, the concentric grid lines representing 2-fold dilution steps and outermost lines representing the highest neutralization (IC50 > 1280). For each virus-plasma combination, the geometric mean IC value is calculated and plotted for each assay, with the points connected within a given assay.

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