Skip to main content

Advertisement

Table 3 Cox-proportional hazard analysis of factors associated with immunological failure among HIV/AIDS patients who started ART from September 2007 to August 2008 at the University of Gondar Hospital

From: The effect of incident tuberculosis on immunological response of HIV patients on highly active anti-retroviral therapy at the university of Gondar hospital, northwest Ethiopia: a retrospective follow-up study

Variables Immunological failure Crude HR (95% CI) P Adjusted HR (95% CI) P
  No Yes     
  no (%) no (%)     
Gender       
  Female 102(71.8) 40(28.2) 1   1  
  Male 209(81) 49(19) 1.54(1.02-2.34) 0.042 1.6(1.01-2.68) 0.046
Age (in year)       
  16-30 130(78.8) 35(21.2) 1    
  31-50 164(77.7) 47(22.3) 1.06(.68-1.63) 0.812   
  > 50 17(70.8) 7(29.2) 1.37(.61-3.09) 0.443   
Education       
  Primary and below 175(76.8) 53(23.2) 1.12(.75-1.74) 0.546   
  Secondary and above 136(79.1) 36(20.9) 1    
WHO HIV clinical stage       
  I 47(82.5) 10(17.5) 1    
  II 65(75.6) 21(24.4) 1.44(.69-3.06) 0.344   
  III 161(77.4) 47(22.6) 1.31(.66-2.59) 0.438   
  IV 38(77.6) 11(22.4) 1.32(.56-3.12) 0.525   
Baseline CD4+ count (cells/mm 3 )       
  0-99 87(69.6) 38(30.4) 1.72(1.13-2.62) 0.012 1.8(1.10-2.92) 0.023
  ≥100 224(81.5) 51(18.5) 1   1  
Initial ART regimen       
  D4T/3TC/NVP or EFV 40(81.6) 9(18.4) 1    
  AZT/3TC/NVP or EFV 141(74.6) 48(25.4) 0.90(.43-1.89) 0.785   
  TDF/3TC/NVP or EFV 130(80.2) 32(19.8) 1.29(.83-2.02) 0.262   
Functional status       
  Working 262(77.1) 78(22.9) 1    
  Ambulatory 39(79.6) 10(20.4) 1.44(.72-2.92) 0.301   
  Bed ridden 10(90.9) 1(9.1) 1.26(.58-2.75) 0.555   
Incident TB       
  Yes 16(61.5) 10(38.5) 1.92(.99-3.72) 0.050 2.2(0.94-5.09) 0.063
  No 295(78.9) 79(21.1) 1   1  
  1. d4T: stavudine; 3TC: lamivudine; NVP: nevirapine; AZT: zidovudine; EFV: efavirenz; TDF: tenofobir; TB: tuberculosis; HIV: human immunodeficiency virus; ART: antiretroviral therapy; IQR: inter-quartile range; SD: standard deviation; WHO: world health organization; HR: hazard ratio, P: p-value.