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Table 5 Virological responses* among HIV-2 –infected patients in 17 studies

From: Antiretroviral therapy response among HIV-2 infected patients: a systematic review

Study VL VL VL VL Delta of VL Slope of VL (first period) Slope of VL (second period) Other response
(Author, year) Threshold Baseline Month-12 Month -24
  % non detectable N, Median [IQR] n, Median [IQR] n, Median [IQR]     
Adje-Touré, 2003 [35] NR 4.5 (4.1-5.2) 4.1 (3.2-4.9) NR NR NR NR  
Van Der Ende, 2003 [28] <2.7 log10 (10%) NR NR NR NR NR NR At week 23, 13/18 (72%) had VL <2.7 log10
Mullins 2004 <2.0 cp log10 NR NR NR NR NR NR Median viral load at the last visit 3.51 [3.27-4.43] log10
Matheron, 2006 [47] NR 3.1 (1.7-4.2) 1.7 (1.7-2.9) 1.7 (1.7-1.7) 12 months: -0.6 (-1.7; 0.0)    
24 months
-0.6 (-2.5; 0)
Ndour, 2006 [41] NR NR NR NR NR NR NR NR
Drylewicz, 2008 [12] <2.7 2.9 NR NR NR <2 months >2 months  
(34%) (2.4-3.7) -0.62 (-0.84; - 0.40) log10 cp/ml/month 0.02 (-0.27; 0.32)
log10 cp/ml/year
Ruelle 2008 [46]   4.1 PI based regimen 8/13 (62%) undectable Without PI 1/6 (17%) undectable PI based regimen 5/8 (63%) undectable Without PI 1/4 (25%) undectable     
(3.4-4.8)
Benard A, 2009 [26] NR 3.3    3 months (n = 20) 80% had undectable VL    
N = 24 (33%) [3.0-3.8]
Jallow, 2009 [32] <2.0 log10 4.9 [4.6-5.2] NR NR NR NR NR NR
Gottlieb, 2009 [29] <1.4 log10 N = 23 (30%) 2.0 [<1.4-4.3] NR NR NR NR NR No resistance
9/11 (82%) had VL <1.4
Resistance 3/12 (25%) had VL <1.4
Harries, 2010 [17] NR NR NR NR NR NR NR NR
Drylewicz 2010 [36] NR NR NR NR NR NR NR NR
Smith 2010 [42] <1.4 log10 2.5 [1.6-4.3] NR NR NR NR NR 35% (n = 74) had detectable RNA plasma HIV-2 at their last follow-up visit. Median 100 [31–1997] copies/ml
Chiara, 2010 [48] NR NR NR NR NR NR NR NR
Peterson 2011 [18] NR 4.9 [4.2-5.4] 81% VL <400 89% VL <400 NR NR NR 19% expressed viral rebound by 36 months
Benard, 2011 [15] <2.7 log10 PI: 4.0 [3.4-4.6] 3NRTIs 4.0 [2.9-4.6] PI: 2.2 3NRTIs 4.0 NR NR 0-3 months 3-12 months  
N = 110 (39%) PI: -0.3 log10/ml/months PI: -0.002 log10/ml/months
3 NRTIs: -0.2 log10/ml/months 3 NRTIs: - +1.6 log10/ml/months
Peterson K, 2012 (56) NR NR NR NR NR NR NR NR
  1. *Included only the studies which reported virological responses.
  2. NR: Not Reported, VL: viral load.