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Table 2 First-line antiretroviral treatment initiated in HIV-2 infected patients in 17 studies

From: Antiretroviral therapy response among HIV-2 infected patients: a systematic review

Study Study period Dual NRTI 3 NRTIs PI-based regimen Boosted PI
(Author, year)   Therapy       
     LPV NFV IDV SQV  
Adje-Touré, 2003 [34] 1998-2000 Yes (n = 6) Yes (n = 1) No Yes (n = 7) Yes (n = 4) No  
Van Der Ende, 2003 [29] 1995-2001 Yes (n = 0) Yes (n = 2) No Yes (n = 1) Yes (n = 14) Yes (n = 3) 80% boosted PI
Mullins 2004$[39] 1994-2003 No Yes (n = 2) No Yes (2 ) Yes (n = 2) Yes [3] Ritonavir boosted PI (n = 2; 22%)
Matheron, 2006 [40] NR- 2004 No Yes (n = 14) No Yes (n = 17) No No Ritonavir boosted PI (n = 23)
Ndour, 2006 [41] 1998-2004 No No No No Yes (n = 35) No No
Drylewicz, 2008 [12] 1996-2006 No NR Yes (n = 14) Yes (n = 10) Yes (n = 1) No Ritonavir-boosted PI (n = 24)
Ruelle 2008 [42] NR-2006 No Yes (n = 6) Yes (n = 4) Yes (n = 3) Yes (n = 5) Yes (n = 1) 4 NRTIs (n = 1) Ritonavir-boosted PI (n = 10)
Benard A, 2009 [28] NR No No Yes (n = 29) No No No Ritonavir-boosted (n = 29; 100%)
Jallow, 2009 [31] 2004-2009 No No Yes (n = 20) No No No Ritonavir-boosted (n = 20; 100%)
Gottlieb, 2009 [23] 2005-NR No No No No Yes (n = 22) No No
Harries 2010 [17] 2002-2008 No Yes (n = 1) Yes (n = 17) Yes (n = 35) Yes (n = 12) No  
Drylewicz 2010 [30] 1997-2007 No Yes (n = 21) NR NR NR NR PI = 193 Ritonavir-boosted (n = 84; 43%)
Smith 2010 [43] NR No Yes (n = 1) Yes (n = 0) No Yes (n = 53) No Ritonavir-boosted (n = 15; 22.4%)
Chiara, 2010 [44] 2006-2009 No Yes (n = 10) NR NR Yes (n = 15) NR Ritonavir-boosted (n = 15; 100%)
Peterson 2011 [18] 2004-2009 NR NR Yes [46] No No No Ritonavir-boosted PI (n = 45, 100%)
Benard, 2011 [15] 1998-2008 No Yes (n = 44) Yes (n = 76) No Yes (n = 18) Yes (n = 16) Ritonavir-boosted PI (n = 126)
Peterson, 2012 [45] NR Yes (n = 0) No Yes (n = 1) Yes (n = 2) Yes (n = 1) Yes (n = 0) One patient on raltegravir as first-line regimen
  1. NR: not reported, NA: not available $ Only the last treatment received was considered