Figure 1

Multiple sequence alignment of TEM amino acid sequences identified in β- lactamase producing Neisseria gonorrhoeae isolates (n = 139) cultured from 2000 to 2011 in 15 WHO European, African, American (North and Latin America), Southeast Asian or Western Pacific countries. The amino acids 3-25 constitute the signal peptide for the mature TEM-1 enzyme. The scheme proposed by Ambler et al. [43] was used for numbering of amino acids.