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Table 2 Summary of subgroup analysis of the included studies by different study characteristics

From: Significance of serum procalcitonin as biomarker for detection of bacterial peritonitis: a systematic review and meta-analysis

Variables No. of studies No. of patients Sensitivity (95% CI) Specificity (95% CI) Diagnostic OR (95% CI) AUROC (95% CI) I 2(95% CI) Likelihood ratio (95% CI) Publication bias (Deek’s test P)
Positive Negative
Serum PCT           
Overall analysis 17 1644 0.83(0.76-0.89) 0.92(0.87-0.96) 61.52(27.58-137.21) 0.94(0.92-0.96) 90.08(80.35-99.81) 11.06(6.31-19.38) 0.18(0.12-0.27) 0.973
PD patients 4 391 0.64(0.47-0.78) 0.91(0.85-0.94) 18.33(6.32-53.12) 0.89(0.87-0.92) 0.00(0.00-100.00) 7.19(3.75-13.82) 0.39(0.24-0.62) 0.629
Cirrhotic patients 11 807 0.86(0.81-0.89) 0.94(0.85-0.97) 85.89(27.31-270.19) 0.91(0.89-0.94) 80.65(58.51-100.00) 13.17(5.27-32.86) 0.15(0.11-0.21) 0.734
High cut-off PCT valuea 9 640 0.68(0.44-0.85) 0.97(0.91-0.99) 60.01(24.19-148.85) 0.95(0.93-0.97) 97.33(95.53-99.13) 20.02(8.29-48.37) 0.33(0.17-0.64) 0.813
Low cut-off PCT valueb 3 529 0.85(0.80-0.88) 0.89(0.79-0.94) 42.57(19.72-91.89) 0.86(0.83-0.89) 61.42(13.01-100.00) 7.42(3.89-14.17) 0.17(0.13-0.23) 0.299
Common PCT cut-off valuec 9 1072 0.81(0.68-0.89) 0.95(0.89-0.98) 75.32(21.13-268.52) 0.95(0.93-0.97) 15.30(0.00-100.00) 15.35(6.67-35.28) 0.20(0.12-0.35) 0.973
Common PCT cut-off in PD 4 391 0.64(0.47-0.78) 0.91(0.85-0.94) 18.33(6.32-53.12) 0.89(0.87-0.92) 0.00(0.00-100.00) 7.19(3.75-13.82) 0.39(0.24-0.62) 0.629
Common PCT cut-off in SBP 5 681 0.87(0.78-0.92) 0.97(0.85-0.99) 245.08(26.73-2247.33) 0.94(0.92-0.96) 60.35(10.58-100.00) 33.02(5.06-215.47) 0.13(0.07-0.23) 0.562
Publication in Chinese 8 905 0.86(0.81-0.89) 0.95(0.89-0.98) 141.09(42.44-469.04) 0.93(0.90-0.95) 30.79(0.00-100.00) 20.12(7.64-52.94) 0.14(0.10-0.19) 0.493
Publication in English 9 739 0.79(0.63-0.89) 0.89(0.81-0.94) 29.16(11.78-72.17) 0.92(0.89-0.94) 91.95(84.48-99.43) 6.99(3.97-12.28) 0.24(0.13-0.44) 0.683
FAS > 0.1 ng/ml 9 704 0.82(0.71-0.90) 0.93(0.85-0.97) 65.43(17.30-247.48) 0.95(0.92-0.96) 48.24(0.00-100.00) 12.26(5.01-29.99) 0.18(0.10-0.33) 0.508
FAS ≤ 0.1 ng/ml 8 940 0.86(0.76-0.92) 0.92(0.85-0.96) 71.41(43.93-116.09) 0.95(0.93-0.97) 89.60(79.27-99.92) 10.76(6.01-19.26) 0.15(0.08-0.26) 0.786
Ascitic PCT           
Overall analysis 5 418 0.79(0.54-0.92) 0.96(0.81-0.99) 80.93(15.26-429.28) 0.96(0.94-0.97) 77.94(52.08-100.00) 17.85(4.11-77.59) 0.22(0.09-0.54) 0.075
Serum CRP           
Overall analysis 7 499 0.76(0.58-0.88) 0.81(0.63-0.92) 13.54(7.25-25.28) 0.85(0.82-0.88) 96.81(94.54-99.09) 4.01(2.16-7.45) 0.29(0.17-0.49) 0.676
  1. Note: PCT procalcitonin, PD peritoneal dialysis, CRP C-reactive protein, SBP Spontaneous bacterial peritonitis, FAS functional assay sensitivities, AUROC area under the receiver operating characteristic curve.
  2. aHigh cut-off valu: greater than 0.5 ng/ml; bLow cut-off value: lesser than 0.5 ng/ml; cCommon PCT Cut-off value: = 0.5 ng/ml.