|
Variables
|
No. of studies
|
No. of patients
|
Sensitivity (95% CI)
|
Specificity (95% CI)
|
Diagnostic OR (95% CI)
|
AUROC (95% CI)
|
I
2(95% CI)
|
Likelihood ratio (95% CI)
|
Publication bias (Deek’s test P)
|
|---|
|
Positive
|
Negative
|
|---|
|
Serum PCT
| | | | | | | | | | |
|
Overall analysis
|
17
|
1644
|
0.83(0.76-0.89)
|
0.92(0.87-0.96)
|
61.52(27.58-137.21)
|
0.94(0.92-0.96)
|
90.08(80.35-99.81)
|
11.06(6.31-19.38)
|
0.18(0.12-0.27)
|
0.973
|
|
PD patients
|
4
|
391
|
0.64(0.47-0.78)
|
0.91(0.85-0.94)
|
18.33(6.32-53.12)
|
0.89(0.87-0.92)
|
0.00(0.00-100.00)
|
7.19(3.75-13.82)
|
0.39(0.24-0.62)
|
0.629
|
|
Cirrhotic patients
|
11
|
807
|
0.86(0.81-0.89)
|
0.94(0.85-0.97)
|
85.89(27.31-270.19)
|
0.91(0.89-0.94)
|
80.65(58.51-100.00)
|
13.17(5.27-32.86)
|
0.15(0.11-0.21)
|
0.734
|
|
High cut-off PCT valuea
|
9
|
640
|
0.68(0.44-0.85)
|
0.97(0.91-0.99)
|
60.01(24.19-148.85)
|
0.95(0.93-0.97)
|
97.33(95.53-99.13)
|
20.02(8.29-48.37)
|
0.33(0.17-0.64)
|
0.813
|
|
Low cut-off PCT valueb
|
3
|
529
|
0.85(0.80-0.88)
|
0.89(0.79-0.94)
|
42.57(19.72-91.89)
|
0.86(0.83-0.89)
|
61.42(13.01-100.00)
|
7.42(3.89-14.17)
|
0.17(0.13-0.23)
|
0.299
|
|
Common PCT cut-off valuec
|
9
|
1072
|
0.81(0.68-0.89)
|
0.95(0.89-0.98)
|
75.32(21.13-268.52)
|
0.95(0.93-0.97)
|
15.30(0.00-100.00)
|
15.35(6.67-35.28)
|
0.20(0.12-0.35)
|
0.973
|
|
Common PCT cut-off in PD
|
4
|
391
|
0.64(0.47-0.78)
|
0.91(0.85-0.94)
|
18.33(6.32-53.12)
|
0.89(0.87-0.92)
|
0.00(0.00-100.00)
|
7.19(3.75-13.82)
|
0.39(0.24-0.62)
|
0.629
|
|
Common PCT cut-off in SBP
|
5
|
681
|
0.87(0.78-0.92)
|
0.97(0.85-0.99)
|
245.08(26.73-2247.33)
|
0.94(0.92-0.96)
|
60.35(10.58-100.00)
|
33.02(5.06-215.47)
|
0.13(0.07-0.23)
|
0.562
|
|
Publication in Chinese
|
8
|
905
|
0.86(0.81-0.89)
|
0.95(0.89-0.98)
|
141.09(42.44-469.04)
|
0.93(0.90-0.95)
|
30.79(0.00-100.00)
|
20.12(7.64-52.94)
|
0.14(0.10-0.19)
|
0.493
|
|
Publication in English
|
9
|
739
|
0.79(0.63-0.89)
|
0.89(0.81-0.94)
|
29.16(11.78-72.17)
|
0.92(0.89-0.94)
|
91.95(84.48-99.43)
|
6.99(3.97-12.28)
|
0.24(0.13-0.44)
|
0.683
|
|
FAS > 0.1 ng/ml
|
9
|
704
|
0.82(0.71-0.90)
|
0.93(0.85-0.97)
|
65.43(17.30-247.48)
|
0.95(0.92-0.96)
|
48.24(0.00-100.00)
|
12.26(5.01-29.99)
|
0.18(0.10-0.33)
|
0.508
|
|
FAS ≤ 0.1 ng/ml
|
8
|
940
|
0.86(0.76-0.92)
|
0.92(0.85-0.96)
|
71.41(43.93-116.09)
|
0.95(0.93-0.97)
|
89.60(79.27-99.92)
|
10.76(6.01-19.26)
|
0.15(0.08-0.26)
|
0.786
|
|
Ascitic PCT
| | | | | | | | | | |
|
Overall analysis
|
5
|
418
|
0.79(0.54-0.92)
|
0.96(0.81-0.99)
|
80.93(15.26-429.28)
|
0.96(0.94-0.97)
|
77.94(52.08-100.00)
|
17.85(4.11-77.59)
|
0.22(0.09-0.54)
|
0.075
|
|
Serum CRP
| | | | | | | | | | |
|
Overall analysis
|
7
|
499
|
0.76(0.58-0.88)
|
0.81(0.63-0.92)
|
13.54(7.25-25.28)
|
0.85(0.82-0.88)
|
96.81(94.54-99.09)
|
4.01(2.16-7.45)
|
0.29(0.17-0.49)
|
0.676
|
- Note: PCT procalcitonin, PD peritoneal dialysis, CRP C-reactive protein, SBP Spontaneous bacterial peritonitis, FAS functional assay sensitivities, AUROC area under the receiver operating characteristic curve.
-
aHigh cut-off valu: greater than 0.5 ng/ml; bLow cut-off value: lesser than 0.5 ng/ml; cCommon PCT Cut-off value: = 0.5 ng/ml.
