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Table 3 Frequencies of KIR genes in the presence of their ligands HLA Class I in patients with leprosy and their clinical forms and healthy individuals in the population of Rondonópolis, MT

From: Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil

KIR – HLA Class I Per se LL Borderline TT Controls
N = 408 N = 21 N = 302 N = 60 N = 413
n (%) n (%) n (%) n (%) n (%)
KIR2DL1 – C2 173 (42.4) 10 (47.6) 121 (40.0) 29 (48.3) 188 (45.5)
KIR2DL1 – C2/C2 82 (20.0) 5 (23.8) 59 (19.5) 14 (23.3) 79 (19.1)
KIR2DL2 – C1 145 (35.5) 8 (38.0) 95 (31.4) 27 (45.0) 134 (32.4)
KIR2DL2 – C1/C1 71 (17.4) 2 (9.52) 56 (18.5) 11 (18.3) 95 (23.0)
KIR2DL3 – C1 174 (42.6) 9 (42.8) 128 (42.3) 26 (43.3) 184 (44.5)
KIR2DL3 – C1/C1 92 (22.5) 3 (14.2) 71 (23.5) 13 (21.6) 116 (28.0)
KIR3DL1 – Bw4 153 (37.5) 7 (33.3) 118 (39.0) 18 (30.0) 164 (39.7)
KIR3DL1 – Bw4/Bw4 44 (10.7) 2 (9.52) 33 (10.9) 7 (11.6) 54 (13.0)
KIR3DL2 – A*03/*11 99 (24.2) 4 (19.0) 74 (24.5) 15 (25.0) 86 (20.8)
KIR2DS1 – C2 70 (17.1) 2 (9.52) 48 (15.8) 14 (23.3) 74 (17.9)
KIR2DS1 – C2/C2 38 (9.31) 2 (9.52) 27 (8.94) 7 (11.6) 25 (6.05)
KIR2DS2 – C1 111 (27.2)a 5 (23.8) 74 (24.5) 20 (33.3)a 85 (20.5)a
KIR2DS2 – C1/C1 51 (12.5) 3 (14.2) 39 (12.9) 6 (10.0) 60 (14.5)
KIR3DS1 – Bw4 57 (13.9) 1 (4.76) 46 (15.2) 7 (11.6) 59 (14.2)
KIR3DS1 – Bw4/Bw4 21 (5.14) 1 (4.76) 16 (5.29) 4 (6.66) 23 (5.56)
KIR2DL2/2DL2 – C1 22 (5.39)b 3 (14.2)b 10 (3.31)b 5 (8.33)b 9 (2.17)b
KIR2DL2/2DL2 – C1/C1 14 (3.43) 0 (0.0) 11 (3.64) 2 (3.33) 10 (2.42)
KIR2DL2/2DL3 – C1 122 (29.9) 6 (28.5) 88 (29.1) 19 (31.6) 124 (30.0)
KIR2DL2/2DL3 – C1/C1 56 (13.7)c 2 (9.52) 43 (14.2) 11 (18.3) 82 (19.8)c
KIR2DL3/2DL3 – C1 55 (13.4) 4 (19.0) 44 (14.5) 5 (8.33) 62 (15.0)
KIR2DL3/2DL3 – C1/C1 34 (8.33) 1 (4.76) 25 (8.27) 4 (6.66) 32 (7.74)
  1. NOTA: Data represent the number of KIR genes and their respective ligands HLA Class I; the values in parentheses correspond to the percentages of each pair KIR-HLA.
  2. TT: Tuberculoid, Borderline (BL, BB, BT), LL: Lepromatous.
  3. a KIR2DS2 – C1: P = 0.031, OR = 1.4 (1.0 – 2.0) to per se vs. controls; P = 0.045, OR = 1.9 (1.1 – 3.5) to TT vs. controls.
  4. b KIR2DL2/2DL2 – C1: P = 0.024, OR = 2.6 (1.2 – 5.6) to per se vs. controls; P = 0.045, OR = 4.1 (1.3 – 12.6) to TT vs. controls; P = 0.032, OR = 7.5 (1.9 – 30.1) to LL vs. controls; P = 0.057 (tendency) to Borderline vs. LL.
  5. c KIR2DL2/2DL3 – C1/C1: P = 0.023, OR = 0.6 (0.4 – 0.9) to per se vs. controls.