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Table 2 Distribution of the frequencies of KIR genes in patients with leprosy and their clinical forms and healthy individuals in the population of Rondonopolis, MT

From: Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil

Genes Per se LL Borderline TT Controls
N = 408 N = 21 N = 302 N = 60 N = 413
n (%) n (%) n (%) n (%) n (%)
KIR2DL1 355 (87.0)a 19 (90.4) 260 (86.0)a 56 (93.3) 397 (96.2)a
KIR2DL2 290 (72.0) 14 (66.6) 209 (69.2) 48 (80.0) 300 (72.6)
KIR2DL3 363 (88.9) 18 (85.7) 272 (90.0) 53 (88.3) 380 (92.0)
KIR2DL4 405 (99.2) 21 (100) 300 (99.3) 60 (100) 409 (99.0)
KIR2DL5 227 (55.6) 8 (38.0) 167 (55.2) 36 (60.0) 225 (54.4)
KIR3DL1 388 (95.0) 21 (100) 286 (94.7) 58 (96.6) 392 (94.9)
KIR3DL2 405 (99.2) 21 (100) 301 (99.6) 59 (98.3) 413 (100)
KIR3DL3 406 (99.5) 21 (100) 301 (99.6) 60 (100) 413 (100)
KIR2DS1 151 (37.0) 5 (23.8) 112 (37.0) 25 (41.6) 156 (37.7)
KIR2DS2 215 (52.6) 10 (47.6) 159 (52.6) 30 (50.0) 197 (47.6)
KIR2DS3 123 (30.1) 4 (19.0) 90 (29.8) 19 (31.6) 129 (60.5)
KIR2DS4 387 (94.8) 21 (100) 286 (94.7) 57 (95.0) 386 (93.4)
KIR2DS5 144 (35.2) 5 (23.8) 107 (35.4) 23 (38.3) 157 (38.0)
KIR3DS1 148 (36.2) 4 (19.0)b 107 (35.4) 26 (43.3)b 153 (37.0)
  1. NOTE: Data represent the number of KIR genes and values in parentheses correspond to the percentages of each gene. TT: Tuberculoid, Borderline (BL, BB, BT), LL: Lepromatous.
  2. a KIR2DL1: P < 0.001, Pc < 0.014, OR = 0.26 (0.15 – 0.48) to per se vs. controls P < 0.001, Pc < 0.014, OR = 0.24 (0.13 – 0.45) to Borderline vs. controls.
  3. b KIR3DS1: P = 0.07 (tendency) to TT vs. LL.