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Table 3 CD4 + T-cell responses in terms of different immune marker expression profiles

From: Superior antigen-specific CD4+T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older

Immune-related marker expression (+/-)

Geometric mean frequenciesa(percentages relative to totals) of CD4+T cells producing immune-related markers/106CD4+T cellsb

IFN-γ

TNF-α

IL-2

CD40L

Day 0

Day 21

Day 42

Day 180

    

TIV/AS03(≥65)

   

+

+

+

+

490 (44)

1075 (31)

937 (37)

670 (37)

+

-

+

+

112 (10)

441 (13)

327 (13)

213 (12)

-

+

+

+

171 (15)

425 (12)

355 (14)

284 (16)

-

-

+

+

114 (10)

356 (10)

308 (12)

172 (10)

+

+

-

+

27 (2)

179 (5)

108 (4)

40 (2)

+

-

-

+

26 (2)

270 (8)

134 (5)

62 (3)

-

+

-

+

32 (3)

106 (3)

67 (3)

50 (3)

-

-

-

+

85 (8)

259 (8)

139 (5)

178 (10)

+

+

+

-

19 (2)

61 (2)

48 (2)

54 (3)

+

-

+

-

6 (1)

35 (1)

17 (1)

13 (1)

-

+

+

-

3 (0)

18 (1)

12 (0)

6 (0)

-

-

+

-

8 (1)

38 (1)

28 (1)

11 (1)

+

+

-

-

4 (0)

28 (1)

17 (1)

12 (1)

+

-

-

-

23 (2)

149 (4)

61 (2)

20 (1)

-

+

-

-

3 (0)

11 (0)

3 (0)

4 (0)

Total

1124 (100)

3451 (100)

2562 (100)

1788 (100)

    

TIV(≥65)

   

+

+

+

+

554 (45)

779 (33)

598 (38)

463 (34)

+

-

+

+

115 (9)

340 (15)

222 (14)

157 (12)

-

+

+

+

187 (15)

327 (14)

229 (15)

209 (16)

-

-

+

+

127 (10)

278 (12)

174 (11)

114 (8)

+

+

-

+

35 (3)

82 (3)

43 (3)

31 (2)

+

-

-

+

25 (2)

144 (6)

54 (3)

39 (3)

-

+

-

+

51 (4)

49 (2)

44 (3)

37 (3)

-

-

-

+

70 (6)

190 (8)

109 (7)

198 (15)

+

+

+

-

12 (1)

35 (1)

28 (2)

41 (3)

+

-

+

-

8 (1)

17 (1)

9 (1)

9 (1)

-

+

+

-

4 (0)

12 (1)

8 (1)

6 (0)

-

-

+

-

10 (1)

27 (1)

16 (1)

9 (1)

+

+

-

-

5 (0)

11 (0)

6 (0)

9 (1)

+

-

-

-

17 (1)

51 (2)

25 (2)

20 (2)

-

+

-

-

3 (0)

4 (0)

3 (0)

4 (0)

Total

1222 (100)

2344 (100)

1568 (100)

1347 (100)

Immune-related marker expression (+/-)

Geometric mean frequencies a (percentages relative to totals) of CD4 + T cells producing immune-related markers/10 6 CD4 + T cells b

IFN-γ

TNF-α

IL-2

CD40L

Day 0

Day 21

Day 42

Day 180

    

TIV(18–40)

   

+

+

+

+

832 (42)

1160 (32)

1007 (36)

863 (34)

+

-

+

+

220 (11)

530 (14)

402 (14)

290 (11)

-

+

+

+

239 (12)

347 (9)

283 (10)

265 (10)

-

-

+

+

182 (9)

389 (11)

306 (11)

256 (10)

+

+

-

+

69 (4)

145 (4)

136 (5)

87 (3)

+

-

-

+

50 (3)

230 (6)

139 (5)

122 (5)

-

+

-

+

56 (3)

101 (3)

87 (3)

53 (2)

-

-

-

+

181 (9)

340 (9)

194 (7)

276 (11)

+

+

+

-

67 (3)

121 (3)

95 (3)

199 (8)

+

-

+

-

13 (1)

61 (2)

31 (1)

46 (2)

-

+

+

-

7 (0)

19 (1)

11 (0)

7 (0)

-

-

+

-

13 (1)

92 (3)

25 (1)

11 (0)

+

+

-

-

9 (0)

34 (1)

22 (1)

25 (1)

+

-

-

-

19 (1)

89 (2)

69 (2)

44 (2)

-

+

-

-

4 (0)

8 (0)

5 (0)

4 (0)

Total

1961 (100)

3669 (100)

2814 (100)

2548 (100)

  1. aNote that the geometric mean frequencies are not adjusted (see Table 2).
  2. bAfter in vitro stimulation with split vaccine antigens from all three (pooled) strains.
  3. TIV, trivalent influenza vaccine; TIV/AS03, AS03-adjuvanted trivalent influenza vaccine.
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BMC Infectious Diseases

ISSN: 1471-2334

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