Single detection of human bocavirus 1 with a high viral load in severe respiratory tract infections in previously healthy children

Table 4 Seven cases with human bocavirus1 single infection at high viral load associated with severe respiratory tract infections

	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
HBoV1 viral load (copies/mL)	3.8 × 10¹¹	7.9 × 10⁸	7.4 × 10⁸	2.5 × 10⁷	6.5 × 10⁹	5.1 × 10⁹	8.4 × 10⁸
Gender	Female	Male	Female	Male	Female	Female	Male
Age (months)	10	3	9	22	9	9	12
Underlying disease	With mild anemia	No	Born at 34 weeks	No	Born at 28 weeks	Born at 35 weeks With mild anemia	No
Duration of symptoms before admission (days)	7	9	15	1	3	4	3
Duration of hospitalization (days)	33	12	6	5	7	8	20
Fever	Yes	Yes	No	No	Yes	Yes	Yes
Cough	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Rhinorrhea	No	No	Yes	No	Yes	No	Yes
Wheezing	Yes	No	Yes	Yes	No	Yes	Yes
Dyspnea	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Diarrhea	No	Yes	No	No	Yes	Yes	No
Weight on admission (kg)	6.0	7.3	6.0	11.0	9.0	7.0	8.0
Body temperature (°C)	38.8	37.7	37.0	37.0	38.4	37.4	39.1
Respiratory rate (/min)	30	67	58	32	50	49	62
Pulse rate (/min)	124	180	145	50	160	145	148
White blood cell (×10⁹ cells/mL)	10.3	15.3	20.6	14.3	12.7	11.8	8.9
Neutrophil granulocyte %	61	26	34	85	68	32	68
Hemoglobin (g/l)	97	107	120	125	120	94	106
Lymphocyte %	35	70	61	12	25	67	26
Platelets (10⁹/L)	354	420	457	352	273	499	265
Chest radiograph	Yes^a	Yes^b	Yes^c	-	Yes^b	Yes^b	Yes^d
Abnormality in blood culture	No	No	No	No	No	No	No
Bacterium in sputum culture	E. coli bacteria	Geleibai coli pneumonia	Streptococcus pneumoniae and Haemophilus influenzae	No	No	No	Streptococcus pneumoniae
Entering the intensive care unit^e	Yes	No	No	No	No	No	Yes
Complication	The right lower pulmonary atelectasis	No	No	No	No	No	No
Final diagnosis	Severe pneumonia	Severe bronchiolitis	Severe pneumonia	Severe pneumonia	Severe pneumonia	Severe pneumonia	Severe pneumonia
Prognosis	Recover	Cure	Cure	Cure	Cure	Recover	Recover

Note: ^aDouble lung inflammation, right lower pulmonary atelectasis; ^bDouble lung texture fuzzy, with visible flocculent shadow and lung inflation is a bit excessive; ^cDouble lung inflammation, light transmittance in left lung is higher than the right lung; ^dDouble lung lesions, the consolidation of the right lung is obvious. ^eThe patient in case 1 received ICU treatment for 25 days and ventilator assisted breathing for 7 days. The patient in case 7 received ICU treatment for 8 days and ventilator assisted breathing for 5 days.

ISSN: 1471-2334