The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study

Table 4 Predictive factors of complicated diseases in patients with EV71 infection

	Uncomplicated EV71 infection (Grade 1) (n = 88)	Complicated EV71 infection (Grade 2 to 4) (n = 136)	pvalue^a
Age (median with range, years)	3.08 (0–15)	2.60 (0–14)	0.06
Gender
Male	56 (64%)	84 (62%)	0.89
Female	32 (36%)	52 (38%)
Fever ^b	72 (82%)	132 (97%)	<0.001
Fever > 3 days	34 (39%)	83 (61%)	0.002
Skin rash	86 (97%)	124 (94%)	0.21
Oral ulcer	85 (97%)	132 (97%)	1.00
Viremia
Yes	23 (26%)	36 (26%)	0.96
No	65 (74%)	100 (74%)
Viral load (median with range, log10 copies/mL)	3.34 (0.88 - 6.99)	3.50 (1.29 - 6.51)	0.80

Values expressed as n(%), unless otherwise indicated.
^aThe chi-square and Fisher’s exact test was used for categorical variables, and the Mann–Whitney test was used for comparison of the viral load.
^bFever was defined as any body temperature over 38 degrees Celsius.

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