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Table 2 Clinical characteristics of patients with and without EV71 viremia

From: The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study

  No Viremia (n = 165) Viremia (n = 59) pvaluea
Age (median with range, years) 2.95 (0–14) 2.12 (0–15) 0.05
  ≤ 1 years old 10 (6%) 14 (24%) <0.001
  > 1 years old 155 (94%) 45 (76%)  
Gender    0.43
  Male 106 (64%) 34 (42%)  
  Female 59 (36%) 25 (58%)  
Skin rash 155 (94%) 58 (98%) 0.30
Oral ulcer 162 (98%) 55 (93%) 0.08
Fever b 152 (92%) 52 (88%) 0.43
Duration of fever (mean ± SD, days) 2.99 ± 1.85 2.38 ± 1.99 0.07
Clinical Severity (Grade 1 to 4)    
Uncomplicated disease 65 (39%) 23 (39%) 0.54d
Complicated disease 100 (61%) 36 (61%)  
Myoclonic jerk or aseptic meningitis 72 (44%) 29 (49%)  
Severe CNS involvement without cardiopulmonary failure 17 (10%) 5 (8%)  
Severe CNS involvement with cardiopulmonary failure 11 (7%) 2 (3%)  
Sample day for PCR test c    
  ≤ 3 days 44 (27%) 40 (68%) <0.001
  > 3 days 121 (73%) 19 (32%)  
Viral load c (median with range, log 10 copies/mL)
  ≤ 3 days   3.68 (0.88 - 6.99) 0.01
  > 3 days   3.13 (1.56 – 4.20)  
  1. Values expressed as n(%), unless otherwise indicated.
  2. aThe chi-square test was used for categorical variables and the Mann–Whitney test was used for comparison of the viral load.
  3. bFever was defined as any body temperature elevation over 38 degrees Celsius.
  4. cCaterorized as days after disease onset.
  5. dStatistical analysis was performed for the difference between patients with uncomplicated and complicated diseases.