The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study

Table 2 Clinical characteristics of patients with and without EV71 viremia

	No Viremia (n = 165)	Viremia (n = 59)	pvalue^a
Age (median with range, years)	2.95 (0–14)	2.12 (0–15)	0.05
≤ 1 years old	10 (6%)	14 (24%)	<0.001
> 1 years old	155 (94%)	45 (76%)
Gender			0.43
Male	106 (64%)	34 (42%)
Female	59 (36%)	25 (58%)
Skin rash	155 (94%)	58 (98%)	0.30
Oral ulcer	162 (98%)	55 (93%)	0.08
Fever ^b	152 (92%)	52 (88%)	0.43
Duration of fever (mean ± SD, days)	2.99 ± 1.85	2.38 ± 1.99	0.07
Clinical Severity (Grade 1 to 4)
Uncomplicated disease	65 (39%)	23 (39%)	0.54^d
Complicated disease	100 (61%)	36 (61%)
Myoclonic jerk or aseptic meningitis	72 (44%)	29 (49%)
Severe CNS involvement without cardiopulmonary failure	17 (10%)	5 (8%)
Severe CNS involvement with cardiopulmonary failure	11 (7%)	2 (3%)
Sample day for PCR test ^c
≤ 3 days	44 (27%)	40 (68%)	<0.001
> 3 days	121 (73%)	19 (32%)
Viral load ^c (median with range, log ₁₀ copies/mL)
≤ 3 days		3.68 (0.88 - 6.99)	0.01
> 3 days		3.13 (1.56 – 4.20)

Values expressed as n(%), unless otherwise indicated.
^aThe chi-square test was used for categorical variables and the Mann–Whitney test was used for comparison of the viral load.
^bFever was defined as any body temperature elevation over 38 degrees Celsius.
^cCaterorized as days after disease onset.
^dStatistical analysis was performed for the difference between patients with uncomplicated and complicated diseases.

ISSN: 1471-2334