The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study

Table 1 Age, gender and clinical severity of patients with EV71 infection

	Case number (n = 224)	Percentage
Age (median with range, years)	2.71 (0–15)
≤ 3 y/o	102	46%
> 3 y/o	122	54%
Gender
Male	140	63%
Female	84	38%
Clinical Severity (Grade 1 to 4)
Uncomplicated disease^a	88	39%
Myoclonic jerk or aseptic meningitis	101	45%
Severe CNS involvement^b without cardiopulmonary failure	22	10%
Severe CNS involvement^b with cardiopulmonary failure	13	6%
Outcomes
Complete recovery	219	98%
With sequelae^c	3	1%
Death	2	1%

^aUncomplicated cases includes uncomplicated HFMD, herpangina or febrile illness.
^bSevere CNS involvement includes encephalitis, encephalomyelitis or polio-like syndrome.
^cAmong the three patients with sequelae, one patient had cervical mye1itis and thoracic spine arachnoiditis and had flaccid paralysis of right arm, another had rhombencephalitis complicated with left arm paralysis and ventilator-dependence after dishcharge, the other had paralysis of left arm and lower limbs and also needed non-invasive positive pressure ventilation after discharge.

ISSN: 1471-2334