Skip to main content
Figure 2 | BMC Infectious Diseases

Figure 2

From: Rate of decline of antibody titers to pandemic influenza A (H1N1-2009) by hemagglutination inhibition and virus microneutralization assays in a cohort of seroconverting adults in Singapore

Figure 2

Model goodness of fit of a multivariate ordered probit model to antibody titre distribution. In orange are HI assays (left column; Figures 2 A, 2 C and 2 E) and MN assays (right column; Figures 2 B, 2 D and 2 F) at three time points in 2009 (Figures 2 A and 2 B), April 2010 (Figures 2 C and 2 D) and September 2010 (Figures 2 E and 2 F), with 95% confidence interval error bars. In black is the posterior predictive distribution (mean and 95% credible interval). The ordered probit model accounts for age and sex as potential confounders, along with individual random effects and a temporal decay in antibodies, and uses the same θ thresholds at all time points. All the non-Gaussian distribution, and evolving shape of the distribution, are apparent, but the flexibility of the model formulation is able to account for both.

Back to article page

BMC Infectious Diseases

ISSN: 1471-2334

Contact us