Skip to main content

Advertisement

Table 3 Prevalence of high-risk and low-risk HPV genotypes as detected by the CLART assay in women aged 23–65 years, by cytology

From: HPV prevalence and genotype distribution in a population-based split-sample study of well-screened women using CLART HPV2 Human Papillomavirus genotype microarray system

  Cytology result     
HPV genotype Normal (N = 4,435) ASCUS (N = 110) LSIL (N = 129) ≥HSIL (N = 96) ≥ASCUS (N = 335)
HPV 16 235 (5.3%) 16 (14.5%) 27 (20.9%) 37 (38.5%) 80 (23.9%)
HPV 18 88 (2.0%) 7 (6.4%) 7 (5.4%) 15 (15.6%) 29 (8.7%)
HPV 31 157 (3.5%) 8 (7.3%) 20 (15.5%) 16 (16.7%) 44 (13.1%)
HPV 33 98 (2.2%) 6 (5.5%) 13 (10.1%) 8 (8.3%) 27 (8.1%)
HPV 35 52 (1.2%) 8 (7.3%) 6 (4.7%) 3 (3.1%) 17 (5.1%)
HPV 39 38 (0.9%) 5 (4.5%) 15 (11.6%) 2 (2.1%) 22 (6.6%)
HPV 45 43 (1.0%) 8 (7.3%) 9 (7.0%) 9 (9.4%) 26 (7.8%)
HPV 51 139 (3.1%) 8 (7.3%) 10 (7.8%) 6 (6.3%) 24 (7.2%)
HPV 52 171 (3.9%) 14 (12.7%) 12 (9.3%) 24 (25.0%) 50 (14.9%)
HPV 56 52 (1.2%) 6 (5.5%) 24 (18.6%) 1 (1.0%) 31 (9.3%)
HPV 58 133 (3.0%) 12 (10.9%) 12 (9.3%) 10 (10.4%) 34 (10.1%)
HPV 59 90 (2.0%) 8 (7.3%) 13 (10.1%) 5 (5.2%) 26 (7.8%)
HPV 66 115 (2.6%) 5 (4.5%) 22 (17.1%) 2 (2.1%) 29 (8.7%)
HPV 68 68 (1.5%) 4 (3.6%) 14 (10.9%) 8 (8.3%) 26 (7.8%)
≥1 high-risk genotype a 923 (20.8%) 61 (55.5%) 93 (72.1%) 88 (91.7%) 242 (72.2%)
Single infection with a high-risk genotype a 388 (8.7%) 22 (20.0%) 20 (15.5%) 37 (38.5%) 79 (23.6%)
Multiple infection including high-risk genotype(s) a 535 (12.1%) 39 (35.5%) 73 (56.6%) 51 (53.1%) 163 (48.7%)
≥1 low-risk genotype a 943 (21.3%) 40 (36.4%) 88 (68.2%) 34 (35.4%) 162 (48.4%)
≥1 low-risk genotype, no high-risk genotype a 530 (12.0%) 17 (15.5%) 32 (24.8%) 4 (4.2%) 53 (15.8%)
No high- or low-risk genotype 2,970 (67.0%) 32 (29.1%) 4 (3.1%) 4 (4.2%) 40 (11.9%)
  1. Abbreviations: ASCUS atypical squamous cells of undetermined significance, HC2 Hybrid Capture 2 assay, HPV Human Papillomavirus, ≥HSIL high-grade intraepithelial lesions or worse, LSIL low-grade squamous intraepithelial lesions.
  2. aCategorization of HPV genotypes into high-risk and low-risk groups followed IARC’s classification [2], according to which genotype 66 is considered “possibly carcinogenic” (low-risk).