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Table 3 Prevalence of high-risk and low-risk HPV genotypes as detected by the CLART assay in women aged 23–65 years, by cytology

From: HPV prevalence and genotype distribution in a population-based split-sample study of well-screened women using CLART HPV2 Human Papillomavirus genotype microarray system

 

Cytology result

    

HPV genotype

Normal (N = 4,435)

ASCUS (N = 110)

LSIL (N = 129)

≥HSIL (N = 96)

≥ASCUS (N = 335)

HPV 16

235 (5.3%)

16 (14.5%)

27 (20.9%)

37 (38.5%)

80 (23.9%)

HPV 18

88 (2.0%)

7 (6.4%)

7 (5.4%)

15 (15.6%)

29 (8.7%)

HPV 31

157 (3.5%)

8 (7.3%)

20 (15.5%)

16 (16.7%)

44 (13.1%)

HPV 33

98 (2.2%)

6 (5.5%)

13 (10.1%)

8 (8.3%)

27 (8.1%)

HPV 35

52 (1.2%)

8 (7.3%)

6 (4.7%)

3 (3.1%)

17 (5.1%)

HPV 39

38 (0.9%)

5 (4.5%)

15 (11.6%)

2 (2.1%)

22 (6.6%)

HPV 45

43 (1.0%)

8 (7.3%)

9 (7.0%)

9 (9.4%)

26 (7.8%)

HPV 51

139 (3.1%)

8 (7.3%)

10 (7.8%)

6 (6.3%)

24 (7.2%)

HPV 52

171 (3.9%)

14 (12.7%)

12 (9.3%)

24 (25.0%)

50 (14.9%)

HPV 56

52 (1.2%)

6 (5.5%)

24 (18.6%)

1 (1.0%)

31 (9.3%)

HPV 58

133 (3.0%)

12 (10.9%)

12 (9.3%)

10 (10.4%)

34 (10.1%)

HPV 59

90 (2.0%)

8 (7.3%)

13 (10.1%)

5 (5.2%)

26 (7.8%)

HPV 66

115 (2.6%)

5 (4.5%)

22 (17.1%)

2 (2.1%)

29 (8.7%)

HPV 68

68 (1.5%)

4 (3.6%)

14 (10.9%)

8 (8.3%)

26 (7.8%)

≥1 high-risk genotype a

923 (20.8%)

61 (55.5%)

93 (72.1%)

88 (91.7%)

242 (72.2%)

Single infection with a high-risk genotype a

388 (8.7%)

22 (20.0%)

20 (15.5%)

37 (38.5%)

79 (23.6%)

Multiple infection including high-risk genotype(s) a

535 (12.1%)

39 (35.5%)

73 (56.6%)

51 (53.1%)

163 (48.7%)

≥1 low-risk genotype a

943 (21.3%)

40 (36.4%)

88 (68.2%)

34 (35.4%)

162 (48.4%)

≥1 low-risk genotype, no high-risk genotype a

530 (12.0%)

17 (15.5%)

32 (24.8%)

4 (4.2%)

53 (15.8%)

No high- or low-risk genotype

2,970 (67.0%)

32 (29.1%)

4 (3.1%)

4 (4.2%)

40 (11.9%)

  1. Abbreviations: ASCUS atypical squamous cells of undetermined significance, HC2 Hybrid Capture 2 assay, HPV Human Papillomavirus, ≥HSIL high-grade intraepithelial lesions or worse, LSIL low-grade squamous intraepithelial lesions.
  2. aCategorization of HPV genotypes into high-risk and low-risk groups followed IARC’s classification [2], according to which genotype 66 is considered “possibly carcinogenic” (low-risk).