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Table 4 Factors associated with development of pulmonary tuberculosis within 12 months after discharge from a tertiary hospital in Botswana

From: Longer hospital stay is associated with higher rates of tuberculosis-related morbidity and mortality within 12 months after discharge in a referral hospital in Sub-Saharan Africa

 

Models including participants who were diagnosed with TB during their inpatient admission, n = 916

Models excluding participants who were diagnosed with TB during their inpatient admission, n = 713

Variable

AOR (95% CI)

AOR (95% CI)

AOR (95% CI)

AOR (95% CI)

AOR 95% C I

AOR (95% CI)

AOR (95% CI)

AOR (95% CI)

Age

21 - 40 years

Reference

Reference

Reference

Reference

Reference

Reference

Reference

Reference

41 - 60 years

1.3 (0.4-4.9)

0.9 (0.3-5.4)

2.5 (0.6-10.7)

2.5 (0.6-10.8)

1.1 (0.2-6.2)

0.9 (0.2-5.8)

1.2 (0.2-8.4)

1.2 (0.2-8.4)

> 60 years

0.9 (0.2-3.5)

1.1 (0.3-4.0)

1.3 (0.2-7.8)

1.5 (0.3-7.6)

2.2 (0.4-10.6)

2.1 (0.4-10.8)

2.9 (0.4-20.5)

2.6 (0.5-14.3)

Sex (male)

1.5 (0.5-4.2)

1.3 (0.5-3.5)

1.7 (0.6-5.1)

1.5 (0.5-4.4)

0.9 (0.2-3.6)

0.9 (0.2-3.6)

0.9 (0.2-4.2)

0.9 (0.2-3.9)

HIV infection*

3.9 (0.8-20.5)

2.9 (0.6-13.1)

2.7 (0.5-15.5)

3.6 (0.6-20.0)

2.8 (0.4-18.4)

2.7 (0.4-17.6)

1.6 (0.2-12.6)

1.6 (0.2-11.7)

CD4 cell* count

CD4 > 350

Reference

Reference

Reference

Reference

Reference

Reference

Reference

Reference

CD4 100 - 350

0.9 (0.4-2.1)

0.9 (0.3-2.0)

0.8 (0.2-2.2)

0.9 (0.4-2.1)

0.8 (0.4-2.0)

1.2 (0.3-8.6)

2.2 (0.4-10.6)

3.4 (0.4-28.8)

CD4 < 100

3.1 (1.3-7.5)

3.6 (1.1–6.9)

3.2 (1.2-7.2)

2.9 (1.2-7.1)

2.8 (1.1-6.6)

3.1 (1.1-12.6)

3.0 (1.1-18.4)

6.5 (0.7-61.3)

Prior history of TB treatment

12.4 (3.7-41.1)

11.9 (3.8-37.4)

4.6 (1.2-17.4)

6.8 (2.0-23.6)

10.6 (2.6-44.0)

7.8 (1.7-36.0)

2.4 (0.4-16-4)

3.1 (0.5-18.6)

Total days admitted to the hospital

2.0 (1.1-3.6)

NA

NA

NA

1.4 (0.6-3.2)

NA

NA

NA

Days spent in the same bay with a TB index case

NA

1.8 (1.1-2.9)

NA

NA

NA

1.5 (0.4-4.4)

NA

NA

Days of adjacent exposure to a TB index case

NA

NA

4.6 (2.2-9.9)

NA

NA

NA

3.4 (1.3-8.9)

NA

TB exposure index

NA

NA

NA

1.9 (1.3-2.8)

NA

NA

NA

2.4 (1.3-4.2)

Inpatient diagnosis of TB

2.6 (0.8-8.6)

1.6 (0.5-5.1)

1.9 (0.6 -6.0)

1.8 (0.6-5.6)

 
  1. *Given collinearity, models including HIV and CD4 cells were developed separately.
  2. Similarly, different models were developed for the variables: a) total days admitted to the hospital; b) days spent in the same bay with a TB index case; c) days of adjacent to a TB index case; and, d) TB exposure score.
  3. Total days admitted to the hospital, days spent in the same bay with a TB index case, days of adjacent to a TB index case were modelled as increments by 10 (days). TB exposure index was modelled as an ordinal variable with increments by 1 point. To calculate the daily exposure index per participant per day, adjacent cases were given twice the weight of non-adjacent ones. For example, if a participant had 2 adjacent TB cases and one non-adjacent TB patient in his/her bay, the “exposure index” for that day would be calculated as: 2x2+1=5.
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BMC Infectious Diseases

ISSN: 1471-2334

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