Table 1 Reported efficacy of azithromycin for treatment of Salmonella Typhi and Salmonella Paratyphi
Author, year | Country | Patients population | Azithromycin dose | Body weights of patients (kg) | Route of administration | Efficacy | MIC of isolates, g/L* | References |
|---|---|---|---|---|---|---|---|---|
Girgis, 1999 | Egypt | n = 36, mean age (range): 19.6 (18–30) | 1 g/day on the first day, followed by 500 mg/day on the next 6 days | NA | Oral | Clinical cure rate: 100% | BMD, MIC*90 (range): 8 (4–16) | [9] |
Butler, 1999 | India | n = 42, mean age (range): 26.2 (17–53) | 500 mg/day for 7 days | Mean 52.2 (range: 40–74) | Oral | Clinical cure rate: 88% (within 8 days), 100% (within 14 days) | BMD MIC*90 (range): 16 (4–32) | [7] |
Chinh, 2000 | Vietnam | n = 44, mean age (range): 26.6 (15–68) | 1 g/day for 5 days | Mean 47.3 (range: 34–60) | Oral | Clinical cure rate: 95.5% | E-test, MIC90 (range): 8 (4–16) | [10] |
Parry, 2007 | Vietnam | n = 62, mean age (range): 10.5 (4–42) | 10 mg/kg/day for 7 days | Mean 24 (range: 12–58) | Oral | Clinical cure rate: 82% | E-test MIC90 (range): 16 (4–32) | [8] |
Dolecek, 2008 | Vietnam | n = 142, median age 11 yrs, (range 1–41) | 20 mg/kg/day for 7 days | Median 24.5 (9.5–57) | Oral | Treatement failure: 9.3% | E-test, MIC90 (range): 12 (4–16) | [11] |