Table 4 HCV HVR1 genetic characteristics in responders and non-responders to PEG-IFN α and ribavirin treatment

Number of patients

12

13

-

HVR1 complexity (number of haplotypes)

≥5%

4.4

5.3

NS

≥2%

8.2

8.8

NS

≥1%

13.4

11.3

NS

Mean Shannon entropy

≥5%

1.28

1.37

NS

≥2%

1.72

1.73

NS

≥1%

2.01

1.87

NS

Mean nucleotide diversity per nucleotide

≥5%

0.132

0.148

NS

≥2%

0.118

0.123

NS

≥1%

0.114

0.112

NS

Mean genetic distance

≥5%

0.187

0.203

NS

≥2%

0.145

0.160

NS

≥1%

0.135

0.164

NS

Number of nucleotide substitutions within HVR1

≥5%

42.8

47.6

NS

≥2%

49.0

52.9

NS

≥1%

59.2

58.4

NS

Percentage of polymorphic amino acid positions

≥5%

59.3

60.0

NS