Empirical antifungal therapy with an echinocandin in critically-ill patients: prospective evaluation of a pragmatic Candida score-based strategy in one medical ICU

Table 4 Independent predictors of death in the patients receiving echinocandin as antifungal therapy with respect to local guidelines, according to 3 different Cox analysis models

	Hazard ratio	95% CI	p
Duration of echinocandin therapy	0.88	0.78–0.99	0.05
RRT on D1	3.05	1.29–7.19	0.01
	Hazard ratio	95% CI	p
Empiric therapy (Yes)	1.50	0.57–3.96	0.41
RRT on D1	3.05	1.29–7.19	0.01
	Hazard ratio	95% CI	p
Duration of echinocandin therapy	0.91	0.81–1.01	0.07
Empiric therapy (Yes)	1.19	0.43–3.25	0.74
RRT on D1	3.20	1.29–8.00	0.01

D: day; SOFA: sequential organ failure assessment; RRT: renal replacement therapy; CI: confidence interval.

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