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Table 3 Diagnosis accuracy of the Candida Score regarding the risk of proven and/or probable IC, as compared with our local guidelines

From: Empirical antifungal therapy with an echinocandin in critically-ill patients: prospective evaluation of a pragmatic Candida score-based strategy in one medical ICU

 

Sensitivity (95% CI)

Specificity (95% CI)

Positive predictive value (95% CI)

Negative predictive value (95% CI)

Positive likelihood ratio

Area under the ROC curve (95% CI)

Candida score & Proven IC

81.0% (58.1–94.5)

47.1% (36.1–58.2)

27.4% (16.8–40.2)

90.9% (78.3–97.5)

1.53

0.64 (0.51–0.76)

Candida score & Proven + probable IC

89.7% (75.8–97.1)

59.7% (47.0–71.5)

56.4% (43.3–69.0)

90.9% (78.3–97.5)

2.23

0.75 (0.65–0.84)

Local guidelines & Proven IC

42.9% (21.8–66.0)

64.7% (53.6–74.8)

23.1% (11.1–39.3)

82.1% (70.8–90.4)

1.21

0.54 (0.40–0.68)

Local guidelines & Proven + probable IC

69.2% (52.4–83.0)

82.1% (70.8–90.4)

69.2% (52.4–83.0)

82.1% (70.8–90.4)

3.86

0.76 (0.66–0.86)

  1. IC: invasive candidiasis; CI: confidence interval; ROC : receiver operating characteristics.