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Table 3 HLA-A, -B, -C, -DRB1 and -DQB1 types in patients with hypothyroidism

From: Common subclinical hypothyroidism during Whipple’s disease

HLA type

Number of individuals

Cohort vs. control

Locus

Allele

Hypothyroidism

Control

Odds Ratio

P 1

HLA-A

01

0

0%

36

28%

N.A

0.19

02

5

71%

55

42%

3.41

> 0.2

03

2

29%

32

25%

1.23

 

24

2

29%

26

20%

1.60

 

26

1

14%

11

8%

1.80

 

29

1

14%

14

11%

1.38

 

32

1

14%

18

14%

1.04

 

68

2

29%

14

11%

3.31

0.19

Total

7

 

130

   

HLA-B

07

1

14%

19

15%

0.97

 

14

2

29%

12

9%

3.93

0.15

15

2

29%

20

15%

2.20

 

27

1

14%

8

6%

2.54

 

35

1

14%

20

15%

0.92

 

38

1

14%

5

4%

4.17

> 0.2

39

1

14%

6

5%

3.44

> 0.3

41

1

14%

4

3%

5.25

> 0.2

44

2

29%

34

26%

1.13

 

51

1

14%

15

12%

1.28

 

55

1

14%

8

6%

2.54

 

Total

7

 

130

   

HLA-C

03

3

43%

26

20%

3.00

0.16

04

1

14%

22

17%

0.82

 

05

2

29%

21

16%

2.08

 

06

1

14%

26

20%

0.67

 

07

3

43%

66

51%

0.73

 

08

2

29%

13

10%

3,60

0,17

12

1

14%

18

14%

1,04

 

15

1

14%

7

5%

2,93

 

Total

7

 

130

   

HLA-DRB1

01

2

25%

27

21%

2,29

 

03

1

13%

24

19%

0,63

 

04

2

25%

36

28%

0,87

 

07

1

13%

19

15%

0,83

 

08

1

13%

9

7%

1,92

 

11

3

38%

36

28%

1,57

 

13

3

38%

38

29%

1,45

 

14

1

13%

13

10%

1,29

 

15

1

13%

24

19%

0,63

 

Total

8

 

130

   

HLA-DQB1

02

2

25%

37

29%

0,84

 

03

4

50%

93

72%

0,40

> 0.2

04

1

13%

5

4%

3,57

> 0.3

05

4

50%

48

37%

1,71

 

06

3

38%

56

43%

0,79

 

Total

8

 

130

   
  1. Odds ratios ≥3 are highlighted in light gray, and odds ratios <0.5 are highlighted in dark gray.
  2. 1: Two-tailed Fisher Exact Test.