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Table 3 Hemagglutination antibody titers of schoolchildren participant sera obtained before, after vaccination and post-season during three consecutive years

From: Geographical heterogeneity and influenza infection within households

 

1st Year

2nd Year

3rd Year

 

TIV(-)

TIV(+)

P

TIV(-)

TIV(+)

P

TIV(-)

TIV(+)

P

 

N = 59

N = 65

 

N = 172

N = 99

 

N = 67

N = 162

 

Pre-vaccination

         

HI-titer≧40

         

  H1N1

-

-

 

155(0.90)

91(0.92)

 

45(0.67)

124(0.77)

 

  H3N2

-

-

 

142(0.83)

77(0.78)

 

17(0.25)

58(0.36)

 

  B

-

-

 

44(0.26)

26(0.26)

 

49(0.73)

104(0.64)

*

GMT #

         

  H1N1

-

-

 

263.78(211.80,315.75)

412.83(246.23,579.42)

*

82.76(60.50,105.02)

89.38(75.14,103.62)

 

  H3N2

-

-

 

210.26(168.06,252.46)

245.91(166.90,324.92)

 

52.54(20.37,84.70)

85.40(57.74,113.06)

 

  B

-

-

 

25.76(21.17,30.34)

30.81(22.25,39.36)

 

69.18(53.71,84.65)

75.43(54.95,95.92)

 

Post-vaccination

         

HI-titer≧40

         

  H1N1

33(0.56)

60(0.92)

*

112(0.65)

61(0.62)

 

37(0.55)

132(0.81)

*

  H3N2

51(0.86)

59(0.91)

 

114(0.66)

61(0.62)

 

6(0.09)

49(0.30)

*

  B

26(0.44)

43(0.66)

*

72(0.42)

39(0.39)

 

23(0.34)

73(0.45)

 

GMT #

         

  H1N1

161.80(91.12,232.48)

422.77(232.82,612.71)

*

408.08(306.32,509.84)

324.14(245.96,402.32)

 

97.76(19.45,176.07)

121.33(100.60,142.06)

 

  H3N2

353.93(253.05,454.81)

411.41(312.73,510.09)

 

487.59(407.64,567.53)

455.61(368.75,542.46)

 

20.82(12.91,28.73)

61.82(41.07,82.57)

*

  B

115.74(67.21,164.28)

114.24(83.34,145.14)

 

46.48(38.09,54.87)

48.59(36.73,60.45)

 

33.13(24.06,42.21)

44.26(33.37,55.15)

 

4-Fold increase (Post vs Pre-vaccination)

       

  H1N1

-

-

 

39(0.23)

17(0.17)

 

11(0.16)

82(0.51)

*

  H3N2

-

-

 

60(0.35)

36(0.36)

 

3(0.04)

15(0.09)

 

  B

-

-

 

62(0.36)

31(0.31)

 

0(0.00)

26(0.16)

*

Post-season

         

HI-titer≧40

         

  H1N1

40(0.68)

60(0.68)

 

154(0.90)

89(0.90)

 

45(0.67)

116(0.72)

 

  H3N2

48(0.82)

59(0.82)

 

163(0.95)

95(0.96)

 

28(0.42)

75(0.46)

 

  B

24(0.40)

43(0.40)

 

167(0.97)

93(0.94)

 

26(0.39)

68(0.42)

 

GMT #

-

-

       

  H1N1

129.26(71.17,187.34)

157.46(68.66,246.25)

 

570.61(497.40,643.82)

503.08(410.42,595.74)

 

132.69(87.48,177.89)

90.52(77.27,103.78)

*

  H3N2

272.46(159.43,385.48)

209.03(120.55,297.52)

 

319.04(269.30,368.79)

390.61(316.43,464.78)

 

99.63(34.88,164.38)

165.77(110.13,221.41)

 

  B

40.43(28.70,52.15)

55.53(38.39,72.67)

 

23.46(20.42,26.50)

24.70(20.09,29.31)

 

31.34(22.69,40.00)

37.87(28.82,46.92)

 
  1. *p < 0.05.
  2. #Numbers in brackets are 95% confidence interval calculated by GEE method.