From: Clinical features and outcome of acute hepatitis B in pregnancy
Variables | Non-pregnant AHB patients N = 87 | Pregnant AHB patients N = 22 | P |
---|---|---|---|
At admission | |||
Days from disease onset to examination | 11.8 ± 7.3 | 11.3 ± 4.1 | 0.70 |
ALT(IU/L) | 1237 (274–3615) | 1025 (285–1797) | 0.039 |
ALT > 1600 IU/L | 27 (31.0%) | 1 (4.5%) | 0.01 |
Bilirubin(μmol/L) | 66.4 (8.2-549.7) | 140 (29.6-289.1) | 0.005 |
Bilirubin > 25 μmol/L | 69 (79.3%) | 22 (100%) | 0.02 |
Albumin(g/L) | 39.0 (28–66) | 33.0 (23.0-42.3) | < 0.001 |
Albumin < 35 g/L | 12 (13.8%) | 14 (63.6%) | < 0.001 |
GGT(IU/L) | 95 (22–425) | 32.5 (21–159) | < 0.001 |
GGT > 64 IU/L | 68 (78.1%) | 4 (18.2%) | < 0.001 |
At discharge | |||
Days from disease onset to examination | 38.6 ± 11.9 | 34.2 ± 7.1 | 0.11 |
ALT(IU/L) | 28 (7–712) | 17 (9–128) | 0.004 |
ALT normalization | 56 (64.4%) | 20 (90.9%) | 0.02 |
Bilirubin(μmol/L) | 15.2 (4.2-212.5) | 19.7 (8–61.4) | 0.27 |
Bilirubin normalization | 65 (74.7%) | 17 (77.3%) | 0.80 |
Albumin(g/L) | 40.4 (32–48.4) | 35 (30–38.8) | < 0.001 |
Albumin normalization | 85 (97.7%) | 12 (54.5%) | < 0.001 |
GGT(IU/L) | 48.0 (10–227) | 28.5 (12–93) | < 0.001 |
GGT normalization | 60 (69.0%) | 20 (90.9%) | 0.04 |
Final follow-up | |||
Months from disease onset to examination | 7.0 ± 0.8 | 6.9 ± 0.7 | 0.54 |
ALT(IU/L) | 20 (5–68) | 12 (6–37) | 0.015 |
ALT normalization | 83 (95.4%) | 22 (100%) | 0.31 |
Bilirubin(μmol/L) | 12.1 (4.2-56) | 13 (5–22) | 0.47 |
Bilirubin normalization | 83 (94.4%) | 22 (100%) | 0.31 |
Albumin(g/L) | 43 (36–48.5) | 39.5 (34–43.0) | < 0.001 |
Albumin < 35 g/L | 0 (0%) | 3 (13.6%) | < 0.001 |
GGT(IU/L) | 37 (10–87) | 20 (12–30) | < 0.001 |
GGT normalization | 80 (91.9%) | 22 (100%) | 0.17 |