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Table 1 Demographic and clinical characteristics of the children with SFTS in comparison with adult patients

From: Severe fever with thrombocytopenia syndrome in children: a case report

Characteristics Pediatric patients Adult patients (N = 180)
  Case1 Case2 Case3 Case4
Demographic features   No. (%)/mean (SD)
Gender Male Female Female Male 80 male (44.4)
Age, y, 6 7 4 15 57.5 (13.0)
History of tick bite Yes No No Yes 29 (16.1)
Close contact with known SFTS patients No Yes Yes No 12 (6.7)
  Mean (range)
Median days from syndromes to admission 3 7 5 4 5 (1–38)
Presenting with clinical manifestations on admission   No. (%) of patients
Fever Yes Yes Yes Yes 177 (98.3)
Malaise Yes Yes Yes Yes 172 (95.6)
Myalgias No No No No 148 (82.2)
Gastrointestinal syndromes Yes Yes Yes No 116 (64.4)
Cough No No No No 63 (35.0)
Sputum production No No No No 46 (25.6)
Dizziness No No No No 42 (23.3)
Headache No No No No 35 (19.4)
Dyspnea No No No No 21 (11.7)
Arthralgias No Yes No No 13 (7.2)
Lymphadenopathy No Yes No No 78 (3.3)
Hematuria No No No No 33 (18.3)
Petechia No No Yes No 25 (13.9)
Hematemesis No No No No 13 (7.2)
Gingival bleeding No No No No 2 (1.1)
Melena No No No No 2 (1.1)
Consciousness disorder No No No No 36 (20.0)
Laboratory measurements on admission   Mean ± SD
WBC (x109/L) 2.3* 1.83* 2.9* 3.3* 3.0 ± 2.3
PLT (x109/L) 118 87* 107 148 71.3 ± 34.6
Neutrophils (%) 52.9 41.7 37.3 72.5 62.0 ± 15.9
Lymphocyte (%) 32.7 43.7 58.1 19.2 29.1 ± 13.0
With abnormal laboratory tests on admission   No. (%) of patients
AST >40 U/L No (14) Yes (521) No (18) No (39) 148 (82.2)
ALT >40 U/L No (32) Yes (178) Yes (55) No (19) 115 (63.9)
ALB <35 g/ No (48.3) No (42.5) No (45.5) No (44.4) 78 (45.6)
ALP >150 U/L Yes (289) Yes (239) Yes (191) No (132) 14 (8.2)
GGT >50 U/L No (10) Yes (52) No (13) No (15) 49 (27.2)
LDH >245 U/L Yes (250) Yes (545) Yes (320) No (236) 136 (75.6)
CK >232 U/L No (89) Yes (1167) No (94) Yes (1012) 128 (71.1)
BUN >7.8 mmol/L No (5.68) No (3.36) No (4.59) No (7.5) 45 (25.0)
CREA >97 mmol/L No (30) No (35) No (35) No (87) 41 (22.8)
Proteinuria No No No No 55 (30.6)
Outcome
Recovery Yes Yes Yes Yes 144 (80.0)
Adverse Outcome No No No No 36 (20.0)
Death No No No No 25 (13.9)
  1. *Denotes abnormal value.
  2. Abbreviations: WBC white blood cell, PLT platelet, HGB hemoglobin, AST aspartate aminotransferase, ALT alanine transaminase, ALB albumin, ALP alkaline phosphatase, GGT gamma-glutamyl transpeptidase, LDH lactate dehydrogenase, CK creatine kinase, BUN blood urea nitrogen, CREA Creatinine.