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Table 7 Sensitivity analysis exploring the influence of the duration of indirect protection against infection

From: 4Flu - an individual based simulation tool to study the effects of quadrivalent vaccination on seasonal influenza in Germany

z Annual mean number of infections with TIV Annual mean number of infections with QIV Annual mean number of infections prevented by QIV Percentage prevented
0 8943 8548 395 4.3
(8885–9001) (8491–8604) (376–414) (4.1-4.5)
7 9024 8617 407 4.3
(8948–9100) (8541–8694) (367–447) (3.9-4.8)
14 9176 9727 449 4.7
(9097–9254) (8652–8802) (409–488) (4.2-5.1)
21 9186 8722 465 4.9
(9114–9259) (8649–8794) (424–505) (4.5-5.3)
28 9151 8732 420 4.3
(9077–9226) (8660–8804) (378–461) (3.9-4.8)
  1. Average annual results (with 95% confidence intervals) obtained for the 20 year evaluation period (calculated from 1,000 simulations for each combination of the unspecific protection and vaccination strategy in a simulated population of about 80,000 individuals (2,000 simulations each for the baseline value indicated by z = 0; boldface line). Indirect protection begins 1 day after infection and ends z days after infection; it prevents infection with any one of the influenza viruses. The last column shows what percentage of all influenza infections which occur under TIV vaccination can additionally be prevented by QIV.