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Table 3 Regimen, spectrum and type of infection

From: The risk of infections in hematologic patients treated with rituximab is not influenced by cumulative rituximab dosage - a single center experience

 

Cases with infections

Number of infectious episodes

Focus of infection

Opportunistic infections

Identified pathogen

Number of CTC grade 3 + 4 infections*

Rituximab monotherapy (n = 23)

4

4

Pneumonia (n = 1)

2

none (n = 2)

3

viral (n = 2)

Opp. Inf. (n = 2)

Bronchitis (n = 1)

R-CHOP/R-CHOEP (n = 88)

53

80

UTI (n = 12)

15

none (n = 47)

66

bacterial (n = 17)

URTI (n = 11)

Opp. inf. (n = 12)

viral (n = 15)

Opp. Pneumonia (n =5)

fungal (n = 3)

Bronchitis (n = 5)

  

FUO (n = 22)

   

Sepsis (n = 2)

   

R-FC/R-FCM (n = 8)

6

9

Bronchitis (n = 3)

2

none (n = 4)

4

bacterial (n = 3)

OppInf (n = 2)

viral (n = 2)

UTI (n = 1)

FUO (n = 2)

Sepsis (n = 1)

R-GMALL/R-DHAP (n = 9)

7

19

UTI (n = 2)

2

none (n = 12)

16

bacterial (n = 5)

Pneumonia (n = 2)

fungal (n = 2)

FUO (n = 8)

Sepsis (n = 4)

URTI (n = 1)

Opp Pneumonia (n = 1)

Sinusitis (n = 1)

R-Gemcitabine (n = 1)

1

1

Pneumonia (n = 1)

none

0

1

R-IMVP16 (n = 2)

2

3

FUO (n = 1)

1

none (n = 2)

3

viral (n = 1)

URTI (n = 1)

OppInf (n = 1)

R-Bendamustine (n = 4)

1

3

Pneumonia (n = 1)

None

none (n = 1)

3

Sepsis (n = 1)

bacterial (n = 2)

UTI (n = 1)

  

R-Other (n = 6)

6

19

FUO (n = 4)

1

none (n = 13)

19

Norovirus (n = 1)

viral (n = 1)

Diarrhea (n = 3)

bacterial (n = 4)

Pneumonia (n = 4)

fungal (n = 1)

Sepsis (n = 3)

Bronchitis (n = 1)

URTI (n = 1)

Sinusitis (n = 1)

 

Opp. Inf. (n =1)

 
  1. UTI = urinary tract infection, URTI = upper respiratory tract infection, FUO = fever of unknown origin, Opp = Opportunistic.
  2. *in 35 cases more than one infection occured.