Table 4 Predictors of unfavorable outcome (compared to cure) assessed at the end of study (n = 392) †
Variable | Univariate | Multivariate‡ | |||
|---|---|---|---|---|---|
OR | 95% CI | OR | 95% CI | ||
Gender | Female | 1 | 1 | ||
Male | 1.29 | 0.70-2.35 | 1.14 | 0.59-2.20 | |
Age | 20-34 | 1 | 1 | ||
35-49 | 1.96* | 1.07-3.57 | 2.14* | 1.11-4.14 | |
≥50 | 2.75** | 1.50-5.05 | 2.97** | 1.51-5.86 | |
Body Mass Index | <18.5 | 1 | 1 | ||
≥18.5 | 0.47** | 0.31-0.73 | 0.33*** | 0.20-0.54 | |
Diabetes | No | 1 | 1 | ||
Yes | 2.47*** | 1.51-4.05 | 2.57** | 1.46-4.52 | |
Alcohol, within 6 months | Less than once a week | 1 | - | ||
Several times a week | 0.52 | 0.26-1.05 | |||
At least once a day | 0.92 | 0.58-1.48 | |||
Smoking, within 6 months | Never smoked | 1 | - | ||
< 1 pack/day | 1.71 | 0.99-2.97 | |||
1 pack/day | 1.14 | 0.66-1.97 | |||
> 1 pack/day | 1.03 | 0.57-1.89 | |||
Residence | Small city and town | 1 | - | ||
Large city | 1.19 | 0.78-1.83 | |||
Education | High school, above | 1 | - | ||
Middle school, below or refusal | 1.40 | 0.92-2.15 | |||
Occupation | Health care, professional and office work | 1 | - | ||
Service sector and laborer | 1.35 | 0.66-2.76 | |||
Unemployment and others | 1.54 | 0.73-3.24 | |||
Chest X-ray | |||||
Grade | Minimal or moderate | 1 | - | ||
Far advanced | 2.09** | 1.35-3.24 | |||
Cavity | No | 1 | - | ||
Yes or not clear | 1.25 | 0.72-2.15 | |||
Nodular lesion | No | 1 | - | ||
Yes or not clear | 1.44 | 0.60-3.48 | |||
Bilateral | Unilateral | 1 | - | ||
Bilateral | 2.67** | 1.38-5.18 | |||
Number of previous treatment episodes | 0 (new case) | 1 | - | ||
1 | 1.7 | 0.90-3.22 | |||
2 | 1.04 | 0.48-2.27 | |||
≥3 | 4.66*** | 2.69-8.08 | |||
History of failure | No | 1 | - | ||
Yes | 3.32*** | 2.11-5.22 | |||
History of TI | No | 1 | - | ||
Yes | 2.26*** | 1.45-3.51 | |||
Number of significant regimen changes | 0 | 1 | - | ||
≥1 | 1.21 | 0.75-1.93 | |||
Drug Susceptibility pattern (n = 401) | DS | 1 | 1 | ||
Mono/poly-R | 1.42 | 0.68-2.97 | 1.45 | 0.67-3.13 | |
Rif, mono-R | 1.69 | 0.42-6.87 | 2.87 | 0.64-12.95 | |
MDR | 3.39*** | 2.09-5.50 | 4.51*** | 2.64-7.68 | |