Table 2 Comparisons of treatment-course related characteristics of study population at the end of therapy by new or previously treated status (n = 669)
Variables (n) | New case | Previously treated case | P-value |
|---|---|---|---|
Number of significant regimen change | |||
0 | 194 (86.6) | 311 (69.9) | <0.001 |
≥1 | 30 (13.4) | 134 (30.1) | |
Elevation of total bilirubin | |||
No | 143 (63.8) | 307 (69.0) | 0.180 |
Yes | 81 (36.2) | 138 (31.0) | |
Elevation of liver enzyme | |||
No | 181 (80.8) | 365 (82.0) | 0.701 |
Yes | 43 (19.2) | 80 (18.0) | |
Months to treatment completion, median (IQR) | 9.45 (8.89-12.23) | 14.97 (9.67-26.10) | <0.001† |
Treatment outcome at EOT | |||
Cured | 154 (68.8) | 181 (40.7) | <0.001* |
Failure | 4 (1.8) | 61 (13.7) | |
TI | 35 (15.6) | 87 (19.6) | |
Unknown | 15 (6.7) | 50 (11.2) | |
Death | 6 (2.7) | 44 (9.9) | |
Withdrawal | 10 (4.5) | 22 (4.9) | |
Culture positivity (since enrollment) | |||
Converted prior to 6 months | 145 (64.7) | 245 (55.1) | 0.001 |
Positivity at 6 months, over | 14 (6.2) | 71 (16.0) | |
Unknown 6 month result | 65 (29.0) | 129 (29.0) | |
Months to TI, median (IQR) | 7.98 (5.02-10.32) | 9.67 (6.60-17.83) | 0.013† |