|
Number of significant regimen change
| | | |
|
0
|
194 (86.6)
|
311 (69.9)
|
<0.001
|
|
≥1
|
30 (13.4)
|
134 (30.1)
| |
|
Elevation of total bilirubin
| | | |
|
No
|
143 (63.8)
|
307 (69.0)
|
0.180
|
|
Yes
|
81 (36.2)
|
138 (31.0)
| |
|
Elevation of liver enzyme
| | | |
|
No
|
181 (80.8)
|
365 (82.0)
|
0.701
|
|
Yes
|
43 (19.2)
|
80 (18.0)
| |
|
Months to treatment completion, median (IQR)
|
9.45 (8.89-12.23)
|
14.97 (9.67-26.10)
|
<0.001†
|
|
Treatment outcome at EOT
| | | |
|
Cured
|
154 (68.8)
|
181 (40.7)
|
<0.001*
|
|
Failure
|
4 (1.8)
|
61 (13.7)
| |
|
TI
|
35 (15.6)
|
87 (19.6)
| |
|
Unknown
|
15 (6.7)
|
50 (11.2)
| |
|
Death
|
6 (2.7)
|
44 (9.9)
| |
|
Withdrawal
|
10 (4.5)
|
22 (4.9)
| |
|
Culture positivity (since enrollment)
| | | |
|
Converted prior to 6 months
|
145 (64.7)
|
245 (55.1)
|
0.001
|
|
Positivity at 6 months, over
|
14 (6.2)
|
71 (16.0)
| |
|
Unknown 6 month result
|
65 (29.0)
|
129 (29.0)
| |
|
Months to TI, median (IQR)
|
7.98 (5.02-10.32)
|
9.67 (6.60-17.83)
|
0.013†
|
