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Table 1 Replication efficiency of laboratory-adapted strains and primary isolates via different coreceptors in NP-2/CD4/coreceptor cell line system

From: CKR-L3, a deletion version CCR6-isoform shows coreceptor-activity for limited human and simian immunodeficiency viruses

Virus Coreceptor in NP-2/CD4 cells:
   CCR5 CXCR4 CKR-L3 CCR6 None
Laboratory isolates      
HIV-1 IIIB - ++++a - - -
  BaL ++++ - - - -
  GUN1wt ++++ ++++ - - -
  GUN1v ++ +++ - - -
  GUN4wt +++ +++ - - -
  GUN4v ++ +++ - - -
HIV-2 CBL23 ++ ++++ - - -
  ROD ++ ++++ - - -
  SBL6669 - ++++ - - -
SIV Mac251 ++++ - - - -
  GBmnd1 ++++ ++ - - -
Primary isolates      
HIV-1 MVP5180 ++++ ++++ - - -
  93BR020 ++++ +++ - - -
  92US723 ++++ - - - -
  HAN2 ++++ ++++ + + -
  GUN11 ++++ ++++ - - -
HIV-2 MIR ++++ ++++ +++ +++ -
SIV smE660 ++++ - +++ ++ -
  1. aViral antigen positive cells were examined by IFA.
  2. ++++,70-90% of cells became antigen-positive within one week after infection; +++,70-90% of cells became antigen-positive within two to four weeks of infection; ++,70-90% of cells became antigen-positive within five to eight weeks of infection; +,1-2% of cells become infected initially, however, did not progress with time untill eight weeks of infection and -,<0.1% of cells became antigen-positive within seven to eight weeks of infection.