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Table 1 Replication efficiency of laboratory-adapted strains and primary isolates via different coreceptors in NP-2/CD4/coreceptor cell line system

From: CKR-L3, a deletion version CCR6-isoform shows coreceptor-activity for limited human and simian immunodeficiency viruses

Virus

Coreceptor in NP-2/CD4 cells:

  

CCR5

CXCR4

CKR-L3

CCR6

None

Laboratory isolates

     

HIV-1

IIIB

-

++++a

-

-

-

 

BaL

++++

-

-

-

-

 

GUN1wt

++++

++++

-

-

-

 

GUN1v

++

+++

-

-

-

 

GUN4wt

+++

+++

-

-

-

 

GUN4v

++

+++

-

-

-

HIV-2

CBL23

++

++++

-

-

-

 

ROD

++

++++

-

-

-

 

SBL6669

-

++++

-

-

-

SIV

Mac251

++++

-

-

-

-

 

GBmnd1

++++

++

-

-

-

Primary isolates

     

HIV-1

MVP5180

++++

++++

-

-

-

 

93BR020

++++

+++

-

-

-

 

92US723

++++

-

-

-

-

 

HAN2

++++

++++

+

+

-

 

GUN11

++++

++++

-

-

-

HIV-2

MIR

++++

++++

+++

+++

-

SIV

smE660

++++

-

+++

++

-

  1. aViral antigen positive cells were examined by IFA.
  2. ++++,70-90% of cells became antigen-positive within one week after infection; +++,70-90% of cells became antigen-positive within two to four weeks of infection; ++,70-90% of cells became antigen-positive within five to eight weeks of infection; +,1-2% of cells become infected initially, however, did not progress with time untill eight weeks of infection and -,<0.1% of cells became antigen-positive within seven to eight weeks of infection.