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Table 3 Clinical characteristics of index case by clinical group

From: Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda

 

PTST-

TSTC

TST+

All

χ 2across all 3 groups

χ 2for PTST- + TSTC vs. TST+

χ 2for PTST- vs. TSTC and TST+

Presence of Cavitary Disease

No

74 (53.2%)

75 (45.5%)

306 (34.7%)

455 (38.4%)

   

Yes

65 (46.8%)

90 (54.5%)

576 (65.3%)

731 (61.6%)

   

All

139

165

882

1186

<0.005*

<0.005*

<0.005*

Baseline Extent of disease on chest x-ray

Normal

18 (12.9%)

9 (5.5%)

40 (4.5%)

67 (5.6%)

   

Minimal

22 (15.8%)

22 (13.3%)

81 (9.2%)

125 (10.5%)

   

Moderate

58 (41.7%)

76 (46.1%)

305 (34.6%)

439 (37.0%)

   

Advanced

41 (29.5%)

58 (35.2%)

456 (51.7%)

555 (46.8%)

   

All

139

165

882

1186

<0.005*

<0.005*

<0.005*

High Index case Smear

None

4 (2.8%)

3 (1.8%)

14 (1.6%)

21 (1.7%)

   

Scanty

5 (3.5%)

1 (0.6%)

11 (1.2%)

17 (1.4%)

   

1+

13 (9.2%)

4 (2.4%)

21 (2.3%)

38 (3.1%)

   

2+

31 (21.8%)

39 (23.2%)

89 (9.9%)

159 (13.1%)

   

3+

89 (62.7%)

121 (72%)

765 (85%)

975 (80.6%)

   

Total

142

168

900

1210

<0.005*

<0.005*

<0.005*

Duration of Cough prior to treatment (days)

Mean (SD)

123.48 (155.876)

118.75 (124.032)

119.49 (119.597)

 

0.150

0.057

0.998

Mycobacterial lineage

Lineage 4 Uganda

57 (46.3%)

71 (47.7%)

415 (54.0%)

543 (52.2%)

   

Lineage 4 non_Uganda

49 (39.8%)

60 (40.3%)

280 (36.4%)

389 (37.4%)

   

Lineage 3

17 (13.8%)

18 (12.1%)

74 (9.6%)

109 (10.5%)

   

Total

123

149

769

1041

0.308

0.101

0.269

  1. PTST- = Persistently negative tuberculin skin test; TSTC = Tuberculin skin test converter; TST + = tuberculin skin test positive at baseline; CI = confidence interval.
  2. Lineage 4 is also known as Euro-American and Lineage 3 is also known as Central Asian [20].
  3. *indicates P value that is significant after multiple testing correction.