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Table 3 Clinical characteristics of index case by clinical group

From: Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda

  PTST- TSTC TST+ All χ 2across all 3 groups χ 2for PTST- + TSTC vs. TST+ χ 2for PTST- vs. TSTC and TST+
Presence of Cavitary Disease
No 74 (53.2%) 75 (45.5%) 306 (34.7%) 455 (38.4%)    
Yes 65 (46.8%) 90 (54.5%) 576 (65.3%) 731 (61.6%)    
All 139 165 882 1186 <0.005* <0.005* <0.005*
Baseline Extent of disease on chest x-ray
Normal 18 (12.9%) 9 (5.5%) 40 (4.5%) 67 (5.6%)    
Minimal 22 (15.8%) 22 (13.3%) 81 (9.2%) 125 (10.5%)    
Moderate 58 (41.7%) 76 (46.1%) 305 (34.6%) 439 (37.0%)    
Advanced 41 (29.5%) 58 (35.2%) 456 (51.7%) 555 (46.8%)    
All 139 165 882 1186 <0.005* <0.005* <0.005*
High Index case Smear
None 4 (2.8%) 3 (1.8%) 14 (1.6%) 21 (1.7%)    
Scanty 5 (3.5%) 1 (0.6%) 11 (1.2%) 17 (1.4%)    
1+ 13 (9.2%) 4 (2.4%) 21 (2.3%) 38 (3.1%)    
2+ 31 (21.8%) 39 (23.2%) 89 (9.9%) 159 (13.1%)    
3+ 89 (62.7%) 121 (72%) 765 (85%) 975 (80.6%)    
Total 142 168 900 1210 <0.005* <0.005* <0.005*
Duration of Cough prior to treatment (days)
Mean (SD) 123.48 (155.876) 118.75 (124.032) 119.49 (119.597)   0.150 0.057 0.998
Mycobacterial lineage
Lineage 4 Uganda 57 (46.3%) 71 (47.7%) 415 (54.0%) 543 (52.2%)    
Lineage 4 non_Uganda 49 (39.8%) 60 (40.3%) 280 (36.4%) 389 (37.4%)    
Lineage 3 17 (13.8%) 18 (12.1%) 74 (9.6%) 109 (10.5%)    
Total 123 149 769 1041 0.308 0.101 0.269
  1. PTST- = Persistently negative tuberculin skin test; TSTC = Tuberculin skin test converter; TST + = tuberculin skin test positive at baseline; CI = confidence interval.
  2. Lineage 4 is also known as Euro-American and Lineage 3 is also known as Central Asian [20].
  3. *indicates P value that is significant after multiple testing correction.