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Table 3 Biomarkers levels measured at time of presentation in dengue fever and leptospirosis

From: Host biomarkers distinguish dengue from leptospirosis in Colombia: a case–control study

  Healthy control (n = 15) Dengue (n = 113) Leptospirosis (n = 47) P value
Dengue vs. Leptospirosis
Angiopoietin-1 44.9 (32.9-53.6) 32.3 (24.1-45.0) 35.8 (29.0-46.7) 0.236
Angiopoietin-2 1.4 (1.0-2.6) 1.8 (1.3-2.5) 2.0 (1.3-3.0) 0.474
sTie-1 8.3 (6.8-12.7) 10.1 (8.1-13.5) 9.0 (7.6-11.6) 0.120
VEGF 0.21 (0.15-0.28) 0.13 (0.05-0.30) 0.24 (0.08-0.49) 0.017
sFlt-1 0.04 (0.04-0.34) 0.04 (0.04-0.88) 0.15 (0.04-0.70) 0.864
C5a 18.5 (13.8-22.1) 53.8 (34.3-63.8) 41.2 (30.2-59.6) 0.103
CRP a 1.8 (1.2-6.1) 19.7 (9.1-41.4) 13.3 (4.1-39.8) 0.125
IL-10 0.02 (0.02-0.16) 0.09 (0.02-0.37) 0.08 (0.02-0.20) 0.688
CHI3L1 44.5 (35.8-61.3) 58.1 (43.0-78.6) 52.1 (36.5-74.1) 0.114
Angiopoietin-like 4 44.7 (30.2-90.9) 40.4 (30.6-57.1) 49.8 (35.9-67.8) 0.094
Angiopoietin-like 3 108 (83–118) 165 (141–195) 122 (96–148) <0.001*
IL-18BP 5.8 (4.4-8.3) 67.8 (41.5-90.9) 11.4 (7.4 (21.5) <0.001*
CXCL10 0.2 (0.2-0.4) 3.2 (1.2-4.4) 0.5 (0.2-1.4) <0.001*
Platelet Factor 4 a 18.5 (15.6-27.1) 25.2 (16.2-39.1) 19.1 (14.0-24.6) <0.001*
sICAM-1 169 (136–187) 352 (300–488) 228 (159–275) <0.001*
Factor D 1143 (1018–1265) 1376 (1172–1615) 970 (837–1128) <0.001*
sEng 6.6 (5.7-8.4) 11.7 (9.6-13.9) 7.6 (7.2-8.2) <0.001*
sKDR 5.3 (4.5-6.1) 6.1 (5.5-7.1) 5.2 (4.6-6.1) <0.001*
sTie-2 8.7 (6.4-9.7) 7.7 (5.9-9.3) 10.0 (7.8-13.0) <0.001*
  1. Biomarker concentrations are presented as median (IQR) in ng/mL unless otherwise indicated, aμg/mL.
  2. *p < 0.05 following adjustment for 19 pair-wise comparisons.