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Figure 2 | BMC Infectious Diseases

Figure 2

From: Host biomarkers distinguish dengue from leptospirosis in Colombia: a case–control study

Figure 2

Integrating Biomarker Data into a Clinical Score Improves Diagnosis of Dengue Fever. A clinical score (from -1 to 2) was created for each study participant by assigning a value of 0 (not present), -1 (more common in leptospirosis) or +1 (more common in dengue) for leukopenia, rash and dizziness. The score was used to create an area under the ROC curve (AUC) of 0.81 (95% CI, 0.73-0.86), p < 0.001. Biomarker data were then integrated into the clinical score (from -1 to 4) by assigning a value of +1 if IL-18BP (>24.5 ng/mL) and sEng (> 9.12 ng/mL) levels were higher than the assigned cut-offs to generate an AUC of 0.96 (95% CI, 0.91-0.98), p < 0.001.

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