Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome

Freitas, Paula; Carvalho, Davide; Santos, Ana Cristina; Madureira, António José; Martinez, Esteban; Pereira, Jorge; Sarmento, António; Medina, José Luís

doi:10.1186/1471-2334-14-347

BMC Infectious Diseases

Table 6 Associations between adipokines and anthropometric and metabolic parameters in patients with and without FMR defined lipodystrophy

From: Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome

	Leptin		Resistin		PAI-1		TNF-α		Adiponectin
Correlation between	Without L	With L	Without L	With L	Without L	With L	Without L	With L	Without L	With L
	n = 96	n = 70	n = 96	n = 74	n = 28	n = 25	n = 101	n = 73	n = 99	n = 75
	r	r	r	r	r	r	r	r	r	r
Age	0.10	−0.01	−0.001	−0.10	−0.09	0.25	0.12	−0.19	0.04	−0.12
Duration of HIV-infection	−0.06	0.38	−0.01	0.23	0.18	−0.11	0.11	0.11	0.13	0.16
Duration of cART	−0.24	0.31	0.04	0.14	0.12	−0.16	0.05	0.05	0.04	0.21
Wais/hip ratio	0.12	0.15	0.05	0.02	0.10	0.14	0.15	−0.01	0.06	−0.19
Thigh circumf.	0.48*	−0.02	−0.17	−0.12	−0.004	0.06	−0.06	−0.02	0.07	0.07
Cervical circumf.	−0.06	−0.24	−0.02	−0.18	0.17	0.11	0.21	−0.03	−0.08	−0.08
Waist circumf.	0.53*	0.20	−0.11	0.03	−0.06	0.18	0.08	−0.01	−0.19	−0.19
Hip circumf.	0.65*	0.15	−0.20	−0.03	−0.07	0.06	−0.04	−0.04	−0.04	−0.04
Arm circumf.	0.47*	−0.06	−0.02	−0.21	−0.13	0.12	0.01	−0.21	−0.07	−0.07
CD4 cell count	−0.09	0.02	−0.01	−0.11	0.29	0.21	0.03	0.02	−0.09	−0.12
BMI	0.66*	0.17	−0.19	−0.09	−0.007	0.04	0.08	−0.02	−0.03	−0.13
Glucose at 0	0.07	−0.03	0.15	0.01	0.08	0.09	0.22	0.002	0.12	0.02
Glucose at 2 h on OGTT	0.25	0.12	0.12	0.12	−0.20	−0.12	0.06	−0.02	−0.02	−0.06
Insulin at 0	0.17	0.31	0.05	0.22	−0.10	0.03	0.09	0.12	−0.08	−0.12
Insulin at 2 h on OGTT	0.36	0.39	0.06	0.17	−0.21	−0.32	0.11	0.19	−0.08	−0.14
HOMA	0.18	0.27	0.08	0.25	−0.03	0.03	0.11	0.11	−0.06	−0.11
A1c	0.15	0.008	0.19	0.11	−0.34	−0.02	0.24	0.00	0.14	−0.02
Triglycerides	−0.004	0.03	0.06	0.17	−0.17	−0.18	−0.13	−0.17	0.08	−0.03
Total cholesterol	0.25	−0.01	−0.01	−0.06	−0.29	0.09	0.18	−0.17	−0.13	0.09
Total fat mass DXA %	0.877*	0.561*	−0.14	0.07	−0.05	−0.05	−0.07	−0.12	−0.17	−0.19
Trunk fat mass DXA %	0.858*	0.547*	−0.14	0.07	−0.05	0.001	−0.02	−0.10	−0.15	−0.20
Leg fat mass DXA %	0.825*	0.464*	−0.15	0.02	−0.06	−0.07	−0.09	−0.13	−0.15	−0.19
Arm fat mass DXA %	0.857*	0.650*	−0.12	0.08	−0.08	−0.19	−0.09	−0.10	−0.21	−0.06
Total fat mass in CT	0.774*	0.515*	−0.19	0.15	−0.07	0.07	0.13	−0.04	−0.08	−0.14
VAT in CT	0.483*	0.119	−0.18	0.14	0.05	0.41	0.05	−0.04	−0.07	−0.19
SAT in CT	0.829*	0.587*	−0.18	0.12	−0.10	−0.01	0.08	−0.06	−0.09	−0.03
_	−0.421*	−0.475*	0.10	−0.04	0.04	0.31	0.002	0.07	0.003	0.004

*p values <0.001 (significant applying the Bonferroni corretion).

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ISSN: 1471-2334

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