Table 4 Sample characteristic, body composition, adipokines and hormones related to body composition according to the presence of lipodystrophy defined by FMR
| Â | Without lipodystrophy | With lipodystrophy | P |
|---|---|---|---|
n (%) | 128 (59.0) | 89 (41.0) | - |
Gender [n (%)] | Â | Â | Â |
Male | 76 (59.4) | 68 (76.4) | Â |
Female | 52 (40.6) | 21 (23.6) | 0.01 |
Age [years, mean (sd)] | 44.7 (12.2) | 49.4 (10.2) | 0.003 |
Duration of HIV infection [years, mean (sd)] | 7.4 (3.9) | 8.6 (3.6) | 0.007 |
cART [years, mean (sd)] | 5.8 (3.8) | 8.0 (3.4) | <0.001 |
Weight [Kg, mean (sd)] | 67.4 (13.0) | 68.3 (11.1) | 0.60 |
BMI [(kg/m2), mean (sd)] | 25.0 (4.8) | 25.3 (4.5) | 0.68 |
Waist circumference [cm, mean (sd)] | 90.2 (12.2) | 92.7 (10.5) | 0.10 |
Hip circumference [cm, mean (sd)] | 95.9 (9.2) | 92.5 (6.7) | 0.002 |
Thigh circumference [cm, mean (sd)] | 48.3 (5.6) | 46.9 (4.8) | 0.07 |
Arm circumference [cm, mean (sd)] | 26.7 (3.2) | 27.2 (2.7) | 0.28 |
Neck circumference [cm, mean (sd)] | 36.4 (3.8) | 37.9 (3.7) | 0.01 |
Waist/hip circumference ratio | 0.94 (0.08) | 1.00 (0.07) | <0.001 |
CD4 cell count [cells/mm3, mean (sd)] | 498.9 (289.4) | 644.6 (354.1) | 0.001 |
HIV RNA (<50) [n (%)] | 109 (85.2) | 81 (91.0) | 0.45 |
HIV risk factor [n (%)] | Â | Â | Â |
Injecting drug user | 36 (28.6) | 17 (19.1) | Â |
Homosexual contact | 7 (5.6) | 16 (18.0) | Â |
Heterosexual contact | 81 (64.3) | 54 (60.7) | Â |
Others | 2 (1.6) | 2 (2.2) | 0.02 |
CDC [n (%)] | Â | Â | Â |
A | 67 (52.8) | 57 (64.0) | 0.16 |
B | 2 (1.6) | 0 (0) | |
C | 58 (45.7) | 32 (36.0) | |
ART [n (%)] | Â | Â | Â |
IP | 65 (52.0) | 48 (53.9) | 0.89 |
NNRTI | 62 (49.6) | 45 (50.6) | 0.89 |
NRTI | 121 (96.8) | 86 (96.6) | 1.00 |
Total Cholesterol [mg/dL, mean (sd)] | 218.1 (56.4) | 233.1 (59.5) | 0.06 |
LDL-cholesterol [mg/dL, mean (sd)] | 125.4 (50.2) | 133.0 (49.4) | 0.27 |
HDL- cholesterol [mg/dL, mean (sd)] | 47.2 (14.6) | 44.4 (11.7) | 0.14 |
Triglycerides [mg/dL, mean (sd)] | 244.8 (117.6) | 300.1 (195.3) | 0.03 |
Uric acid [mg/L, mean (sd)] | 43.8 (14.3) | 51.0 (15.1) | <0.001 |
Systolic blood pressure [mmHg, mean (sd)] | 120.0 (18.6) | 124.8 (15.6) | 0.04 |
Diastolic blood pressure [mmHg, mean (sd)] | 75.7 (11.8) | 78.1 (10.5) | 0.14 |
Glucose 0 [mg/dL, mean (sd)] | 103.0 (39.5) | 114.4 (43.7) | 0.002 |
Glucose 2 h at OGTT [mg/dL, mean (sd)] | 123.9 (42.9) | 139.7 (49.0) | 0.03 |
Insulin 0 [μU/mL, mean (sd)] | 9,96 (10.50) | 12.96 (10.55) | 0.005 |
Insulin 2 h at OGTT [μU/mL, mean (sd)] | 49. 8 (40.1) | 88.3 (142.2) | 0.005 |
HOMA [mean (sd)] | 2.65 (3. 01) | 3.70 (3.28) | <0.001 |
QUICKI [mean (sd)] | 0.37 (0.10) | 0.34 (0.4) | <0.001 |
hsCRP [mg/dL, mean (sd)] | 0.50 (0.90) | 0.36 (0.27) | 0.28 |
Adiponectin [μg/mL, mean (sd)] | 5.64 (7.39) | 3.95 (4.49) | 0.23 |
Leptin [ng/mL, mean (sd)] | 7.3 (8.5) | 3.9 (3.3) | 0.008 |
Resistin [ng/mL, mean (sd)] | 12.8 (13.4) | 12.8 (7.4) | 0.37 |
Ghrelin[pg/mL, mean (sd)] | 117.4 (133.6) | 118.1 (106.7) | 0.45 |
PAI-1 [pg/mL, mean (sd)] | 62.6 (43.6) | 102.1 (110.1) | 0.26 |
TNF-α [pg/mL, mean (sd)] | 61.9 (50.3) | 52.3 (33.9) | 0.43 |
Adiponectin/leptin ratio [mean (sd)] | 2.72 (7.21) | 1.69 (3.13) | 0.42 |
Fat mass [%, mean (sd)] DXA | Â | Â | Â |
Total | 24.8 (13.1) | 19.3 (8.5) | 0.002 |
Trunk | 25.7 (13.3) | 24.3 (9.0) | 0.53 |
Leg | 24.4 (14.7) | 11.1 (7.4) | <0.001 |
Arm | 27.2 (17.1) | 20.3 (13.6) | 0.001 |
Fat mass [Kg, mean (sd)] DXA | Â | Â | Â |
Total | 17.3 (11.1) | 13.2 (7.3) | 0.02 |
Trunk | 9.3 (6.0) | 9.0 (4.8) | 0.69 |
Leg | 5.2 (3.6) | 2.1 (1.6) | <0.001 |
Arm | 2.1 (1.9) | 1.5 (1.2) | 0.008 |
Body Fat Mass by Quantitative CT | Â | Â | Â |
Total [cm2, mean (sd)] | 282.9 (174.9) | 276.5 (126.6) | 0.92 |
VAT [cm2, mean (sd)] | 111.2 (85.4) | 139.4 (68.7) | <0.001 |
SAT [cm2, mean (sd)] | 171.7 (125.9) | 117.0 (92.4) | 0.001 |
VAT/SAT ratio [mean (sd)] | 1.07 (1.46) | 2.44 (2.60) | <0.001 |