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Table 1 Grading system for methodological quality of individual studies[15]

From: Development of quality indicators for antimicrobial treatment in adults with sepsis

  Intervention Aetiology, prognosis
A1 Systematic review of at least two independent A2-level studies
A2 Randomised Controlled Trial (RCT) of sufficient methodological quality and power Prospective cohort study with sufficient power and with adequate confounding corrections
B Comparative Study lacking the same quality as mentioned at A2 (including patient-control and cohort studies) Prospective cohort study lacking the same quality as mentioned at A2, retrospective cohort study or patient-control study
C Non-comparative study
D Expert opinion