Table 1 Grading system for methodological quality of individual studies[15]
From: Development of quality indicators for antimicrobial treatment in adults with sepsis
| Â | Intervention | Aetiology, prognosis |
|---|---|---|
A1 | Systematic review of at least two independent A2-level studies | |
A2 | Randomised Controlled Trial (RCT) of sufficient methodological quality and power | Prospective cohort study with sufficient power and with adequate confounding corrections |
B | Comparative Study lacking the same quality as mentioned at A2 (including patient-control and cohort studies) | Prospective cohort study lacking the same quality as mentioned at A2, retrospective cohort study or patient-control study |
C | Non-comparative study | |
D | Expert opinion | |