Table 1 Analysis model inputs
From: Cost effectiveness of a pentavalent rotavirus vaccine in Oman
Parameter | Base case value (Range for one-way sensitivity analysis) | Source |
|---|---|---|
Birth cohort | 65500 | Birth Registry DG-PL |
Deaths | 6 (4.8,7.2) | Al Awaidy 2009, Parashar 2004 |
Hospitalizations | 4279 (3423, 5135) | Al Awaidy 2009 |
ED Visits | 3294 (2,635, 3,953) | Al Awaidy 2009, Howidi 2012 |
Office visits | 14,838 (11870, 17,806) | Al Awaidy 2009, Parashar 2003 &2006 |
Average hospital length of stay | 3 days | Al Awaidy 2009 |
Distribution of health care contacts by type | Al Awaidy 20091 | |
Vaccine efficacy (assumed rate reduction) for complete series | ||
Deaths and hospitalizations | 88% | Vesikari et al. 2006 |
Office visits | 86% | Vesikari et al. 2006 |
Parental work loss | Howidi, 2012 | |
Days of work loss for episodes requiring death/hospitalization | 2 | Assumption |
Days of work loss for episodes requiring ED visits | 1 | Assumption |
Days of works loss for episodes requiring office visits | 0.50 | Assumption |
Days of works loss for episodes requiring no care | 0.50 | Assumption |
Percentage of working parents who missed work for episodes involving deaths/hospitalizations | 100% | Assumption |
Percentage of working parents who missed work for episodes involving outpatient visits and no care | 100% | Assumption |
Vaccine Coverage | 94%: 3 doses, 3%: 2 doses, 3%: 1 dose | WHO |
Health care and vaccination costs,OMR [USD] | ||
Hospital day | 71 (57, 85) [184.6 (148.2, 221)] | Al Awaidy 2009 |
ED visit | 27 (21.6, 32.4) [70.2 (56.16,84.24)] | Al Awaidy, 2009 |
Office visit | 27 (21.6, 32.4) [70.2 (56.16,84.24)] | Al Awaidy 2009 |
Day of missed work | 11.40 [29.64] | |
Direct non-medical care for hospitalizations or deaths | 12.5 [32.5] | Assumption |
Direct non-medical care for ED visits | 7.5 [19.5] | Assumption |
Direct non-medical outpatient visits and no care | 7.5[19.5] | Assumption |
Price per dose | 7.69 [19.994] | |
Administration fee per dose | 0 | Assumption |
QALY decrement per rotavirus episode | 0.0058 (0.0022, 0.0133) | Brisson et al. 2010 |