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Table 3 Clinical outcome related to treatment characteristics

From: Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls

Treatment characteristics Death proportion (%) NDI proportion (%)
  [p valuea] [p valueb]
Empiric antifungal therapy 3/8 (38) [1.00] 2/5 (40) [0.64]
Antifungal therapy commenced within 48 hours of diagnosis 14/32 (44) [0.92] 8/16 (50) [0.76]
Adequate doses attained within 48 hours of commencing antifungal therapy 17/39 (44) [0.83] 13/20 (65) [0.56]
cSingle drug therapy 14/25 (56) [0.22] 5/11 (45) [0.72]
dSingle sequential therapy 0/7 (0) [0.08] 1/6 (17) [0.17]
Received ≤ 14 days of treatment 9/13 (69) [0.11] 2/4 (50) [1.00]
  1. aReference proportion refers to proportion of deaths among infants commencing antifungal treatment =18/45 (40%).
  2. bReference proportion refers to proportion of confirmed NDI among infants who completed therapy and were discharged =15/27 (56%).
  3. cReceived only 1 drug for entire course of therapy.
  4. dReceived ≥ 2 drugs over entire course, but only 1 drug administered at any given time.