Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls

Table 3 Clinical outcome related to treatment characteristics

Treatment characteristics	Death proportion (%)	NDI proportion (%)
	[p value^a]	[p value^b]
Empiric antifungal therapy	3/8 (38) [1.00]	2/5 (40) [0.64]
Antifungal therapy commenced within 48 hours of diagnosis	14/32 (44) [0.92]	8/16 (50) [0.76]
Adequate doses attained within 48 hours of commencing antifungal therapy	17/39 (44) [0.83]	13/20 (65) [0.56]
^cSingle drug therapy	14/25 (56) [0.22]	5/11 (45) [0.72]
^dSingle sequential therapy	0/7 (0) [0.08]	1/6 (17) [0.17]
Received ≤ 14 days of treatment	9/13 (69) [0.11]	2/4 (50) [1.00]

^aReference proportion refers to proportion of deaths among infants commencing antifungal treatment =18/45 (40%).
^bReference proportion refers to proportion of confirmed NDI among infants who completed therapy and were discharged =15/27 (56%).
^cReceived only 1 drug for entire course of therapy.
^dReceived ≥ 2 drugs over entire course, but only 1 drug administered at any given time.

ISSN: 1471-2334