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Congenital candidiasis
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IC within the first 7 days of life
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Severe intraventricular hemorrhage (IVH)
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Any IVH event ≥ grade 2
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Definite CNS candidiasis
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Positive CSF or brain culture or yeast forms on histopathology of brain
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Probable CNS candidiasis
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Positive blood culture for Candida plus at least one of:
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CSF WBC count >25 x 106/L in a non-bloody CSF
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CSF protein ≥2.0 g/L
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CSF/serum glucose ratio <0.5
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Head ultrasound compatible with CNS candidiasis
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Cerebral palsy (CP)
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A non-progressive disorder characterized by abnormal tone in one or more extremities and abnormal control of movement and posture
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Moderate to severe CP
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Not yet walking at assessment
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Severe CP
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Unable to sit
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Blindness
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Visual acuity <20/200 in either eye
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Visual impairment
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Any visual deficit correctable with glasses
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Deafness
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Hearing deficit requiring hearing aids or cochlear implants
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Hearing impairment
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Any hearing deficit not requiring hearing aids or implants
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Neurodevelopmental impairment
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Any of the following: blindness, deafness, moderate to severe cerebral palsy, or score <70 in PDI or MDI of the BSID-II
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Candida infection contributing to death
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Any of the following: death occurring within 48 hours of a positive culture of Candida from a sterile site, death occurring within 48 hours of commencing appropriate antifungal therapy, or documented microbiological or histopathological evidence of Candida infection in a normally sterile site at autopsy
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