Condition | Definition |
---|---|
Congenital candidiasis | IC within the first 7 days of life |
Severe intraventricular hemorrhage (IVH) | Any IVH event ≥ grade 2 |
Definite CNS candidiasis | Positive CSF or brain culture or yeast forms on histopathology of brain |
Probable CNS candidiasis | Positive blood culture for Candida plus at least one of: |
CSF WBC count >25 x 106/L in a non-bloody CSF | |
CSF protein ≥2.0 g/L | |
CSF/serum glucose ratio <0.5 | |
Head ultrasound compatible with CNS candidiasis | |
Cerebral palsy (CP) | A non-progressive disorder characterized by abnormal tone in one or more extremities and abnormal control of movement and posture |
Moderate to severe CP | Not yet walking at assessment |
Severe CP | Unable to sit |
Blindness | Visual acuity <20/200 in either eye |
Visual impairment | Any visual deficit correctable with glasses |
Deafness | Hearing deficit requiring hearing aids or cochlear implants |
Hearing impairment | Any hearing deficit not requiring hearing aids or implants |
Neurodevelopmental impairment | Any of the following: blindness, deafness, moderate to severe cerebral palsy, or score <70 in PDI or MDI of the BSID-II |
Candida infection contributing to death | Any of the following: death occurring within 48 hours of a positive culture of Candida from a sterile site, death occurring within 48 hours of commencing appropriate antifungal therapy, or documented microbiological or histopathological evidence of Candida infection in a normally sterile site at autopsy |