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Table 1 Study definitions

From: Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls

Condition Definition
Congenital candidiasis IC within the first 7 days of life
Severe intraventricular hemorrhage (IVH) Any IVH event ≥ grade 2
Definite CNS candidiasis Positive CSF or brain culture or yeast forms on histopathology of brain
Probable CNS candidiasis Positive blood culture for Candida plus at least one of:
  CSF WBC count >25 x 106/L in a non-bloody CSF
  CSF protein ≥2.0 g/L
  CSF/serum glucose ratio <0.5
  Head ultrasound compatible with CNS candidiasis
Cerebral palsy (CP) A non-progressive disorder characterized by abnormal tone in one or more extremities and abnormal control of movement and posture
Moderate to severe CP Not yet walking at assessment
Severe CP Unable to sit
Blindness Visual acuity <20/200 in either eye
Visual impairment Any visual deficit correctable with glasses
Deafness Hearing deficit requiring hearing aids or cochlear implants
Hearing impairment Any hearing deficit not requiring hearing aids or implants
Neurodevelopmental impairment Any of the following: blindness, deafness, moderate to severe cerebral palsy, or score <70 in PDI or MDI of the BSID-II
Candida infection contributing to death Any of the following: death occurring within 48 hours of a positive culture of Candida from a sterile site, death occurring within 48 hours of commencing appropriate antifungal therapy, or documented microbiological or histopathological evidence of Candida infection in a normally sterile site at autopsy