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Table 7 Mean values of A/H1N1/California/7/2009-specific Abs and IFN-γ production in blood from study participants with or without pdm flu vaccination and reported either symptoms or no symptoms of ILI

From: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

  Vacc + & Sym+ Vacc + & Sym- Vacc- & Sym+ Vacc- & Sym-
  A C P A C P A C p A C P
  SRH (mm 2 ), geometric mean
A/H1N1/California 20.6 28.7 <0.001 20.4 28.2 < 0.001 14.8 18.1 0.4 20.4 20.7 0.9
  IFN-γ (pg/mL)
A/H1N1/Brisbane 126 339 <0.001 115 279 <0.001 156 163 0.2 128 158 0.04
A/H1N1/Solomon s/3/2006 97 293 <0.001 90 231 <0.001 121 164 0.2 108 140 0.001
A/H3N2/Uruguay 195 350 <0.001 162 297 <0.001 224 256 0.3 170 233 <0.01
A/H3N2/Wisconsin 207 346 <0.001 170 294 <0.001 247 264 0.4 200 245 0.04
A/H5N1/Vietnam 346 426 0.03 325 427 <0.001 336 382 0.3 347 363 0.7
B/Florida 231 316 0.04 202 230 0.06 280 286 0.8 230 267 0.09
B/Malaysia 138 204 0.03 129 163 <0.01 191 221 0.4 157 183 0.1
M1 31 81 <0.01 27 51 <0.001 37 26 0.3 30 36 0.5
M2 18 18 0.3 18 20 0.03 18 18 0.3 18 20 0.5
CFP-10 21 19 0.3 22 24 0.4 18 18 0.9 21 22 0.5
PHA 513 521 0.3 495 513 0.05 500 546 0.15 516 534 0.3
Mean IFN-γ 165 240   151 211   173 199   164 192  
N 69 69   312 312   48 48   208 208  
  1. The Wilcoxon-Mann–Whitney rank-sum test was used to calculate the p-values (difference between time point A and B). Note the increased antigen-specific cellular immune responses in blood from participants who did not receive the vaccine and did not report any ILI symptoms. P values below 0.05 are indicated in bold.
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