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Table 6 Mean values of A/H1N1/California/7/2009-specific Abs and IFN-γ production in study participants who tested positive for H1N1 or coronavirus

From: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

  H1N1 positives Corona positives HCB HCC
  A B C AB1 AC1 A B C AB1 AC1 p
  SRH (mm2), geometric mean p-value SRH (mm2), geometric mean p-value  
A/H1N1/California 16.1 46.9 30.6 <0.001 0.003 21.1 29.8 24.3 0.2 0.4 <0.001 0.001
  IFN-γ (pg/mL)
A/H1N1/Brisbane 90 460 274 <0.001 0.01 156 227 159 0.6 0.2 <0.001 0.01
A/H1N1/Solomon 104 416 272 <0.001 0.01 124 212 159 0.2 0.2 <0.01 0.03
A/H3N2/Uruguay 125 420 292 <0.001 0.09 222 224 244 0.8 0.4 <0.001 0.09
A/H3N2/Wisconsin 137 408 298 <0.001 0.02 212 236 242 0.5 0.4 0.001 0.04
A/H5N1/Vietnam 316 546 392 <0.01 0.3 355 394 367 0.7 0.8 <0.01 0.3
B/Florida 218 307 327 0.24 0.2 216 370 240 0.08 0.7 0.4 0.1
B/Malaysia 173 260 251 0.06 0.25 160 249 177 0.2 0.5 0.7 0.11
M1 34 127 48 <0.01 0.08 18 24 25 0.04 0.15 0.07 0.25
M2 19 18 19 0.3 0.9 18 18 18 0.9 0.9 0.4 0.9
CFP-10 19 25 18 0.9 0.3 18 18 18 0.6 0.3 0.9 0.7
PHA 502 535 588 0.9 0.08 524 589 544 0.1 0.5 0.2 0.25
Mean IFN-γ diff. 148 265 233    173 220 189     
N 21 21 21    38 15 38     
  1. The Wilcoxon-Mann–Whitney rank-sum test was used to calculate the p-values. AB1: difference between time point A and B; AC1: difference between time point A and C; HCB: difference between pdmH1N1 positive and coronavirus positive at time point B. HCC difference between pdmH1N1 positive and coronavirus positive at time point C. Note the strong immune responses at time point B in participants with pdmH1N1 infection; this response was reduced at the end of the study (time point C). P values below 0.05 are indicated in bold.
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