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Table 4 Mean values of A/H1N1/California/7/2009-specific Abs and IFN-γ production in study participants with or without pdmH1N1 vaccination who did not report any symptoms of ILI during the 2009–2010 flu season

From: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

 

Not vaccinated

Vaccinated

Difference

 

A

C

C-A

A

C

C-A

C-A V-N1

p-value

 

SRH (mm 2 ), geometric mean

  

A/H1N1/California

20.9

23.3

2.4

18.8

28.6

9.8

7.4

<0.001

 

IFN-γ (pg/mL), mean

  

A/H1N1/Brisbane

134

164

30

101

234

134

105

<0.01

A/H1N1/ Solomon

117

142

25

60

190

130

105

<0.001

A/H3N2/Uruguay

167

232

64

148

256

109

37

0.07

A/H3N2/Wisconsin

172

243

71

145

253

108

37

0.4

A/H5N1/Vietnam

338

338

0

307

395

88

88

0.03

B/Florida

233

275

42

196

208

12

−27

0.6

B/Malaysia

155

197

42

125

141

15

−27

0.3

M1

32

29

−3

22

49

27

30

<0.01

M2

18

22

4

18

18

0

−4

0.9

CFP-10

19

18

−1

20

23

3

4

0.2

PHA

501

538

37

517

519

2

−35

0.8

Mean IFN-γ diff.

163

191

28

144

198

53

25

 

N

94

94

 

120

120

   
  1. The Wilcoxon-Mann–Whitney rank-sum test was used to calculate the p-values (comparison of C-A between vaccinated and unvaccinated). 1V-N is vaccinated minus unvaccinated. Listed are Ab responses (top panel, directed against A/H1N1 California, mean and confidence interval) and IFN-γ responses directed against a broad panel of flu targets (designated the flu A or flu B strains), and against matrix proteins M1 and M2. CFP10 served as control. PHA was the positive control stimulus. P values below 0.05 are indicated in bold.
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BMC Infectious Diseases

ISSN: 1471-2334

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