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Table 4 Mean values of A/H1N1/California/7/2009-specific Abs and IFN-γ production in study participants with or without pdmH1N1 vaccination who did not report any symptoms of ILI during the 2009–2010 flu season

From: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

  Not vaccinated Vaccinated Difference
  A C C-A A C C-A C-A V-N1 p-value
  SRH (mm 2 ), geometric mean   
A/H1N1/California 20.9 23.3 2.4 18.8 28.6 9.8 7.4 <0.001
  IFN-γ (pg/mL), mean   
A/H1N1/Brisbane 134 164 30 101 234 134 105 <0.01
A/H1N1/ Solomon 117 142 25 60 190 130 105 <0.001
A/H3N2/Uruguay 167 232 64 148 256 109 37 0.07
A/H3N2/Wisconsin 172 243 71 145 253 108 37 0.4
A/H5N1/Vietnam 338 338 0 307 395 88 88 0.03
B/Florida 233 275 42 196 208 12 −27 0.6
B/Malaysia 155 197 42 125 141 15 −27 0.3
M1 32 29 −3 22 49 27 30 <0.01
M2 18 22 4 18 18 0 −4 0.9
CFP-10 19 18 −1 20 23 3 4 0.2
PHA 501 538 37 517 519 2 −35 0.8
Mean IFN-γ diff. 163 191 28 144 198 53 25  
N 94 94   120 120    
  1. The Wilcoxon-Mann–Whitney rank-sum test was used to calculate the p-values (comparison of C-A between vaccinated and unvaccinated). 1V-N is vaccinated minus unvaccinated. Listed are Ab responses (top panel, directed against A/H1N1 California, mean and confidence interval) and IFN-γ responses directed against a broad panel of flu targets (designated the flu A or flu B strains), and against matrix proteins M1 and M2. CFP10 served as control. PHA was the positive control stimulus. P values below 0.05 are indicated in bold.
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