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Table 2 Mean values of A/H1N1/California/7/2009-specific Abs (measured by SRH) and IFN-γ production in the whole-blood assay before (A) and after (C) the 2009/2010 flu season in study participants with our without pdm flu vaccination

From: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

Time point A C A C
  pdm vaccination   
  Vacc. Not vacc. Vacc. Not vacc. V/NV1-diff.
  SRH (mm2), geometric mean   
A/H1N1/California 20.1 (18.5–21.8) 19.3 (17.3–21.4) 27.9 (26.4–29.5) 20.7 (18.9–22.6) 0.3 <0.001
  IFN-γ (pg/mL), mean   
A/H1N1/Brisbane 139 133 285 169 0.3 <0.001
A/H1N1/Solomon 119 113 246 151 0.2 <0.001
A/H3N2/Uruguay 194 177 304 238 0.2 <0.001
A/H3N2/Wisconsin 203 195 301 251 0.6 <0.01
A/H5N1/Vietnam 346 352 423 373 0.6 <0.01
B/Florida 221 250 245 283 0.1 0.04
B/Malaysia 145 168 167 200 0.15 0.07
M1 33 34 63 34 0.8 <0.01
M2 18 18 20 20 0.4 0.8
CFP-10 21 21 24 22 0.7 0.2
PHA 501 513 506 545 0.13 0.02
N 437 232 437 232   
Mean age, years 47 41 47 41 <0.001 <0.001
  1. The Wilcoxon-Mann–Whitney rank-sum test was used to calculate p-values. 1V/NV: vaccinated vs. unvaccinated. Listed are Ab responses (top panel, directed against A/H1N1 California, mean and confidence interval) and IFN-γ responses directed against a broad panel of flu targets (designated the flu A or flu B strains), and against matrix proteins M1 and M2. CFP10 served as control. PHA was the positive control stimulus. P values below 0.05 are indicated in bold.
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