A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory Syndrome in a Kenyan population

Table 2 The prevalence of IL-23R genotypes in patients undergoing HAART (IRIS) and non-IRIS

Genotype	IRIS	Non-IRIS	P-value
rs7530511
CC	17 (70.83)	33 (76.74)	0.518^a
CT	5 (20.83)	9 (20.93)
TT	2 (8.33)	1 (2.33)
rs1884444
GG	4 (18.18)	16 (39.02)	0.091^a
GT	16 (72.73)	18 (43.90)
TT	2 (9.09)	7 (17.07)
rs11465754
AA	7 (26.92)	16 (38.10)	0.426^a
AG	16 (61.54)	19 (45.24)
GG	3 (11.54)	7 (16.67)
rs6682925
CC	10 (38.46)	19 (48.72)	0.393^a
CG	13 (50.00)	13 (33.33)
GG	3 (11.54)	7 (17.95)
rs7539625
GG	5 (20.83)	16 (36.36)	0.088^a
GA	17 (70.83)	19 (43.18)
AA	2 (8.33)	9 (20.45)

^aData are proportions (%) as determined by Fishers’ exact test. The targeted variants were those that had a prevalence of >10% in reference African Yoruba population (dbSNP and HAP-MAP). There were no significant differences in proportions of the variants in IRIS versus non-IRIS patients.

ISSN: 1471-2334