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Table 2 Clinical characteristics and outcomes of KPC(+) patients

From: Quantifying the clinical virulence of Klebsiella pneumoniae producing carbapenemase Klebsiella pneumoniae with a Galleria mellonellamodel and a pilot study to translate to patient outcomes

 

Patient characteristics

KPC susceptibilities (mg/L)

Patient treatment and outcome

Age

Modified APACHE II score, day 0

Antibiotics received prior to culture

Bacteremia source

Ertapenem MIC

Imipenem MIC

Meropenem MIC

Directed therapy*

Outcome

55

10

Vancomycin, tobramycin

Lung

>8

8

≥16

None

Died

79

18

Ciprofloxacin

PICC line, wound

>8

8

≥16

Meropenem

Died

68

13

Vancomycin, meropenem

Lung/GU

Not done

2

4

Meropenem

Died

65

22

Meropenem, cefepime, gentamicin, vancomycin

GU

>32

>32

>16

Cefepime, tigecycline, amikacin

Died

54

6

Piperacillin/tazobactam, vancomycin, tobramycin, meropenem, colistin

GU

Not done

8

≥16

Tobramycin, meropenem, colistin, tigecycline, gentamicin

Died

40

13

None

GU

≥8

≥16

≥16

Cefepime

Discharge home

38

11

Piperacillin/tazobactam, vancomycin, gentamicin, linezolid

Kidney

4

1

1

Cefepime, gentamicin, colistin

Discharge home

75

21

None

GI/GU

>32

4

2

Piperacillin/tazobactam, tigecycline, gentamicin, fosfomycin

Discharge home

64

9

Ciprofloxacin, meropenem, vancomycin, aztreonam, tigecycline

GU

32

16

2

Cefepime, fosfomycin, tigecylcine, colistin

Discharge home

59

10

None

GU

>8

4

2

Meropenem, colistin, amikacin, tigecycline, tobramcyin

Discharge home

58

13

Vancomycin, piperacillin/tazobactam, tigecycline

PICC line

32

16

Not done

Cefepime, amikacin

Transfer to LTAC

55

8

Vancomycin, meropenem

PICC line, wound

>8

>16

>16

Colistin, tigecycline, cefepime

Transfer to LTAC

64

10

None

Intraabdominal

12

4

1

Meropenem, tigecycline, imipenem/cilastatin, colistin, piperacillin/tazobactam

Transfer to LTAC

67

15

Cefepime, ciprofloxacin, gentamicin, linezolid

GU likely

>8

4

2

Cefepime, gentamicin

Transfer to rehab

52

2

Ciprofloxacin, cefazolin, vancomycin

Unknown

Not done

8

Not done

Piperacillin/tazobactam, ciprofloxacin, cefepime, gentamicin, colistin, meropenem, tigecycline

Transfer to rehab

  1. GU = genitourinary, GI = gastrointestinal, PICC = peripherally inserted central catheter, LTAC = long term acute care, Rehab = rehabilitation organization.
  2. *Directed therapy was defined as antibiotics received after culture results were available.