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Table 2 Clinical characteristics and outcomes of KPC(+) patients

From: Quantifying the clinical virulence of Klebsiella pneumoniae producing carbapenemase Klebsiella pneumoniae with a Galleria mellonellamodel and a pilot study to translate to patient outcomes

  Patient characteristics KPC susceptibilities (mg/L) Patient treatment and outcome
Age Modified APACHE II score, day 0 Antibiotics received prior to culture Bacteremia source Ertapenem MIC Imipenem MIC Meropenem MIC Directed therapy* Outcome
55 10 Vancomycin, tobramycin Lung >8 8 ≥16 None Died
79 18 Ciprofloxacin PICC line, wound >8 8 ≥16 Meropenem Died
68 13 Vancomycin, meropenem Lung/GU Not done 2 4 Meropenem Died
65 22 Meropenem, cefepime, gentamicin, vancomycin GU >32 >32 >16 Cefepime, tigecycline, amikacin Died
54 6 Piperacillin/tazobactam, vancomycin, tobramycin, meropenem, colistin GU Not done 8 ≥16 Tobramycin, meropenem, colistin, tigecycline, gentamicin Died
40 13 None GU ≥8 ≥16 ≥16 Cefepime Discharge home
38 11 Piperacillin/tazobactam, vancomycin, gentamicin, linezolid Kidney 4 1 1 Cefepime, gentamicin, colistin Discharge home
75 21 None GI/GU >32 4 2 Piperacillin/tazobactam, tigecycline, gentamicin, fosfomycin Discharge home
64 9 Ciprofloxacin, meropenem, vancomycin, aztreonam, tigecycline GU 32 16 2 Cefepime, fosfomycin, tigecylcine, colistin Discharge home
59 10 None GU >8 4 2 Meropenem, colistin, amikacin, tigecycline, tobramcyin Discharge home
58 13 Vancomycin, piperacillin/tazobactam, tigecycline PICC line 32 16 Not done Cefepime, amikacin Transfer to LTAC
55 8 Vancomycin, meropenem PICC line, wound >8 >16 >16 Colistin, tigecycline, cefepime Transfer to LTAC
64 10 None Intraabdominal 12 4 1 Meropenem, tigecycline, imipenem/cilastatin, colistin, piperacillin/tazobactam Transfer to LTAC
67 15 Cefepime, ciprofloxacin, gentamicin, linezolid GU likely >8 4 2 Cefepime, gentamicin Transfer to rehab
52 2 Ciprofloxacin, cefazolin, vancomycin Unknown Not done 8 Not done Piperacillin/tazobactam, ciprofloxacin, cefepime, gentamicin, colistin, meropenem, tigecycline Transfer to rehab
  1. GU = genitourinary, GI = gastrointestinal, PICC = peripherally inserted central catheter, LTAC = long term acute care, Rehab = rehabilitation organization.
  2. *Directed therapy was defined as antibiotics received after culture results were available.