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Table 1 Demographic and clinical characteristics of patients with K. pneumoniae blood stream infections stratified by KPC status

From: Quantifying the clinical virulence of Klebsiella pneumoniae producing carbapenemase Klebsiella pneumoniae with a Galleria mellonellamodel and a pilot study to translate to patient outcomes

Characteristic KPC(+) (n = 15) KPC(−) (n = 60) p-value
Age (mean, SD) 59.5 (11.3) 59.6 (17) 0.98
Gender, female 32 (53.3) 8 (53.3) 0.99
Modified APACHE II score (mean, SD) 12.1 (5.4) 10.8 (4.2) 0.31
Prior hospitalization 12 (80) 28 (46.7) 0.02
Neutropenic 1 (6.7) 1 (1.7) 0.36
Renal dysfunction 3 (20) 10 (16.7) 0.72
Liver dysfunction 2 (13.3) 5 (8.3) 0.62
Diabetes 3 (20) 10 (16.7) 0.72
Current immunosuppressive therapy 1 (6.7) 11 (18.3) 0.44
LOS prior to positive culture (median, IQR) 2 (1–12) 1 (1–1) <0.01
Time to directed therapy (hrs) (median, IQR) 4 (0–24) 6 (3–13) 0.46
K. pneumoniae cultured from >1 site 11 (73.3) 19 (31.7) <0.01
Total days of antibiotics post infection (median, IQR) 13 (8–18) 6.5 (4–10) <0.01
  1. Note: Data are no. (%) of patients unless otherwise indicated.
  2. KPC = Klebsiella pneumoniae producing carbapenemase, APACHE = Acute Physiology and Chronic Health Evaluation, LOS = length of stay, SD = standard deviation, IQR = interquartile range.