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Table 1 Demographic and clinical characteristics of patients with K. pneumoniae blood stream infections stratified by KPC status

From: Quantifying the clinical virulence of Klebsiella pneumoniae producing carbapenemase Klebsiella pneumoniae with a Galleria mellonellamodel and a pilot study to translate to patient outcomes

Characteristic

KPC(+) (n = 15)

KPC(−) (n = 60)

p-value

Age (mean, SD)

59.5 (11.3)

59.6 (17)

0.98

Gender, female

32 (53.3)

8 (53.3)

0.99

Modified APACHE II score (mean, SD)

12.1 (5.4)

10.8 (4.2)

0.31

Prior hospitalization

12 (80)

28 (46.7)

0.02

Neutropenic

1 (6.7)

1 (1.7)

0.36

Renal dysfunction

3 (20)

10 (16.7)

0.72

Liver dysfunction

2 (13.3)

5 (8.3)

0.62

Diabetes

3 (20)

10 (16.7)

0.72

Current immunosuppressive therapy

1 (6.7)

11 (18.3)

0.44

LOS prior to positive culture (median, IQR)

2 (1–12)

1 (1–1)

<0.01

Time to directed therapy (hrs) (median, IQR)

4 (0–24)

6 (3–13)

0.46

K. pneumoniae cultured from >1 site

11 (73.3)

19 (31.7)

<0.01

Total days of antibiotics post infection (median, IQR)

13 (8–18)

6.5 (4–10)

<0.01

  1. Note: Data are no. (%) of patients unless otherwise indicated.
  2. KPC = Klebsiella pneumoniae producing carbapenemase, APACHE = Acute Physiology and Chronic Health Evaluation, LOS = length of stay, SD = standard deviation, IQR = interquartile range.